TY - JOUR
T1 - ABO and Rhesus blood groups and risk of type 2 diabetes
T2 - evidence from the large E3N cohort study
AU - Fagherazzi, Guy
AU - Gusto, Gaëlle
AU - Clavel-Chapelon, Françoise
AU - Balkau, Beverley
AU - Bonnet, Fabrice
N1 - Funding Information:
The study is supported by the Mutuelle Générale de l’Education Nationale, the Institut de Cancérologie Gustave Roussy and the Institut National de la Santé et de la Recherche Médicale. The validation of potential diabetes cases was supported by the European Union (Integrated Project LSHM-CT-2006–037197 in Framework Programme 6 of the European Community) InterAct project. Study sponsors had no role in designing the study, data analysis or interpretation, writing the manuscript, or the decision to submit the manuscript for publication.
Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2015/3
Y1 - 2015/3
N2 - Aims/hypothesis: The objective of this study was to evaluate the relationship of ABO blood type (A, B, AB and O), Rhesus factor (positive or negative) and a combination of the two (ABO × Rhesus) with type 2 diabetes mellitus risk.Methods: In total, 82,104 women from the large prospective E3N cohort were followed between 1990 and 2008. Multivariate Cox regression models were used to estimate HRs and 95% CIs.Results: Those with either the A (HR 1.10 [95% CI 1.02, 1.18]) or B (HR 1.21 [95% CI 1.07, 1.36]) group were at increased risk of type 2 diabetes mellitus compared with those with the O group. The association with the AB group did not reach statistical significance (HR 1.17 [95% CI 0.99, 1.39]). There was no difference in type 2 diabetes mellitus risk between Rhesus positive and negative groups (HR 0.96 [95% CI 0.88, 1.05]). When the universal donors (O−) were taken as the reference category, we observed an increased risk for both A+ (HR 1.17 [95% CI 1.02, 1.35]) and A− (HR 1.22 [95% CI 1.03, 1.45]) individuals. The greatest increase in risk was seen for those with the B+ blood group (HR 1.35 [95% CI 1.13, 1.60]). We also observed a greater type 2 diabetes mellitus risk for those with the AB+ group (HR 1.26 [95% CI 1.02, 1.57]). Adjustment for fasting plasma glucose and lipid concentrations in a case–control subsample did not alter the associations.Conclusions/interpretation: This study suggests that people with the O blood type have a lower risk of developing type 2 diabetes mellitus. Therefore, blood group should be investigated in future clinical and epidemiological studies on diabetes, and further pathophysiological research is needed to determine why individuals with blood type O have a lower risk of type 2 diabetes mellitus.
AB - Aims/hypothesis: The objective of this study was to evaluate the relationship of ABO blood type (A, B, AB and O), Rhesus factor (positive or negative) and a combination of the two (ABO × Rhesus) with type 2 diabetes mellitus risk.Methods: In total, 82,104 women from the large prospective E3N cohort were followed between 1990 and 2008. Multivariate Cox regression models were used to estimate HRs and 95% CIs.Results: Those with either the A (HR 1.10 [95% CI 1.02, 1.18]) or B (HR 1.21 [95% CI 1.07, 1.36]) group were at increased risk of type 2 diabetes mellitus compared with those with the O group. The association with the AB group did not reach statistical significance (HR 1.17 [95% CI 0.99, 1.39]). There was no difference in type 2 diabetes mellitus risk between Rhesus positive and negative groups (HR 0.96 [95% CI 0.88, 1.05]). When the universal donors (O−) were taken as the reference category, we observed an increased risk for both A+ (HR 1.17 [95% CI 1.02, 1.35]) and A− (HR 1.22 [95% CI 1.03, 1.45]) individuals. The greatest increase in risk was seen for those with the B+ blood group (HR 1.35 [95% CI 1.13, 1.60]). We also observed a greater type 2 diabetes mellitus risk for those with the AB+ group (HR 1.26 [95% CI 1.02, 1.57]). Adjustment for fasting plasma glucose and lipid concentrations in a case–control subsample did not alter the associations.Conclusions/interpretation: This study suggests that people with the O blood type have a lower risk of developing type 2 diabetes mellitus. Therefore, blood group should be investigated in future clinical and epidemiological studies on diabetes, and further pathophysiological research is needed to determine why individuals with blood type O have a lower risk of type 2 diabetes mellitus.
KW - ABO
KW - Blood group
KW - Cohort
KW - Diabetes
KW - Risk factor
UR - http://www.scopus.com/inward/record.url?scp=84925539781&partnerID=8YFLogxK
U2 - 10.1007/s00125-014-3472-9
DO - 10.1007/s00125-014-3472-9
M3 - Article
C2 - 25533388
AN - SCOPUS:84925539781
SN - 0012-186X
VL - 58
SP - 519
EP - 522
JO - Diabetologia
JF - Diabetologia
IS - 3
ER -