Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Xian Wen Yang; Su Mei Li; Yong Li Li; Jia Han Xia; Liang Wu; Yun Heng Shen; Jun Mian Tian; Ning Wang; Yonghong Liu; Wei Dong Zhang

doi:10.1002/ejoc.201001203

Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Xian Wen Yang
, Su Mei Li
, Yong Li Li
, Jia Han Xia
, Liang Wu
, Yun Heng Shen
, Jun Mian Tian
, Ning Wang
, Yonghong Liu
, Wei Dong Zhang^*

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

27 Citations (Scopus)

Abstract

Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

Original language	English
Pages (from-to)	6531-6534
Number of pages	4
Journal	European Journal of Organic Chemistry
Issue number	34
DOIs	https://doi.org/10.1002/ejoc.201001203
Publication status	Published - Dec 2010

Keywords

Abies delavayi
Lactones
Natural products
Nitric oxide
Spiro compounds
Terpenoids

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10.1002/ejoc.201001203

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title = "Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi",

abstract = "Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.",

keywords = "Abies delavayi, Lactones, Natural products, Nitric oxide, Spiro compounds, Terpenoids",

author = "Yang, \{Xian Wen\} and Li, \{Su Mei\} and Li, \{Yong Li\} and Xia, \{Jia Han\} and Liang Wu and Shen, \{Yun Heng\} and Tian, \{Jun Mian\} and Ning Wang and Yonghong Liu and Zhang, \{Wei Dong\}",

year = "2010",

month = dec,

doi = "10.1002/ejoc.201001203",

language = "English",

pages = "6531--6534",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag",

number = "34",

}

TY - JOUR

T1 - Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

AU - Yang, Xian Wen

AU - Li, Su Mei

AU - Li, Yong Li

AU - Xia, Jia Han

AU - Wu, Liang

AU - Shen, Yun Heng

AU - Tian, Jun Mian

AU - Wang, Ning

AU - Liu, Yonghong

AU - Zhang, Wei Dong

PY - 2010/12

Y1 - 2010/12

N2 - Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

AB - Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

KW - Abies delavayi

KW - Lactones

KW - Natural products

KW - Nitric oxide

KW - Spiro compounds

KW - Terpenoids

UR - https://www.scopus.com/pages/publications/78649603156

U2 - 10.1002/ejoc.201001203

DO - 10.1002/ejoc.201001203

M3 - Article

AN - SCOPUS:78649603156

SN - 1434-193X

SP - 6531

EP - 6534

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 34

ER -

Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Abstract

Keywords

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