Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Xian Wen Yang; Su Mei Li; Yong Li Li; Jia Han Xia; Liang Wu; Yun Heng Shen; Jun Mian Tian; Ning Wang; Yonghong Liu; Wei Dong Zhang

doi:10.1002/ejoc.201001203

Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Xian Wen Yang, Su Mei Li, Yong Li Li, Jia Han Xia, Liang Wu, Yun Heng Shen, Jun Mian Tian, Ning Wang, Yonghong Liu, Wei Dong Zhang^*

^*Corresponding author for this work

Department of Cancer Research

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

Original language	English
Pages (from-to)	6531-6534
Number of pages	4
Journal	European Journal of Organic Chemistry
Issue number	34
DOIs	https://doi.org/10.1002/ejoc.201001203
Publication status	Published - Dec 2010

Keywords

Abies delavayi
Lactones
Natural products
Nitric oxide
Spiro compounds
Terpenoids

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10.1002/ejoc.201001203

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title = "Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi",

abstract = "Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.",

keywords = "Abies delavayi, Lactones, Natural products, Nitric oxide, Spiro compounds, Terpenoids",

author = "Yang, {Xian Wen} and Li, {Su Mei} and Li, {Yong Li} and Xia, {Jia Han} and Liang Wu and Shen, {Yun Heng} and Tian, {Jun Mian} and Ning Wang and Yonghong Liu and Zhang, {Wei Dong}",

year = "2010",

month = dec,

doi = "10.1002/ejoc.201001203",

language = "English",

pages = "6531--6534",

journal = "European Journal of Organic Chemistry",

issn = "1434-193X",

publisher = "Wiley-VCH Verlag",

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T1 - Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

AU - Yang, Xian Wen

AU - Li, Su Mei

AU - Li, Yong Li

AU - Xia, Jia Han

AU - Wu, Liang

AU - Shen, Yun Heng

AU - Tian, Jun Mian

AU - Wang, Ning

AU - Liu, Yonghong

AU - Zhang, Wei Dong

PY - 2010/12

Y1 - 2010/12

N2 - Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

AB - Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

KW - Abies delavayi

KW - Lactones

KW - Natural products

KW - Nitric oxide

KW - Spiro compounds

KW - Terpenoids

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U2 - 10.1002/ejoc.201001203

DO - 10.1002/ejoc.201001203

M3 - Article

AN - SCOPUS:78649603156

SN - 1434-193X

SP - 6531

EP - 6534

JO - European Journal of Organic Chemistry

JF - European Journal of Organic Chemistry

IS - 34

ER -

Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Abstract

Keywords

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