Abiespiroside A, an unprecedented sesquiterpenoid spirolactone with a 6/6/5 ring system from Abies delavayi

Xian Wen Yang, Su Mei Li, Yong Li Li, Jia Han Xia, Liang Wu, Yun Heng Shen, Jun Mian Tian, Ning Wang, Yonghong Liu, Wei Dong Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Abstract

Abiespiroside A (1), a unique sesquiterpenoid spirolactone with a 6/6/5 ring system, was isolated from Abies delavayi Franch. The structure was established as (1R,5R,6R,7S,9R)-6,9α-epoxy-9,15-bisabolanolide-5-O-β- D-glucopyranoside by extensive analysis of various spectroscopic data and further confirmation by the single-crystal X-ray diffraction. It showed potent inhibitory activity against the production of nitric oxide in RAW264.7 macrophages stimulated by lipopolysaccharides.

Original languageEnglish
Pages (from-to)6531-6534
Number of pages4
JournalEuropean Journal of Organic Chemistry
Issue number34
DOIs
Publication statusPublished - Dec 2010

Keywords

  • Abies delavayi
  • Lactones
  • Natural products
  • Nitric oxide
  • Spiro compounds
  • Terpenoids

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