TY - JOUR
T1 - Abdominal obesity, weight gain during adulthood and risk of liver and biliary tract cancer in a European cohort
AU - Schlesinger, Sabrina
AU - Aleksandrova, Krasimira
AU - Pischon, Tobias
AU - Fedirko, Veronika
AU - Jenab, Mazda
AU - Trepo, Elisabeth
AU - Boffetta, Paolo
AU - Dahm, Christina C.
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Halkjær, Jytte
AU - Fagherazzi, Guy
AU - Boutron-Ruault, Marie Christine
AU - Carbonnel, Franck
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Lagiou, Pagona
AU - Palli, Domenico
AU - Grioni, Sara
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Hb, Bueno De Mesquita
AU - Van Den Berg, Saskia
AU - Peeters, Petra H.M.
AU - Braaten, Tonje
AU - Weiderpass, Elisabete
AU - Quirós, J. Ramón
AU - Travier, Noémie
AU - Sánchez, María José
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Dorronsoro, Miren
AU - Lindkvist, Björn
AU - Regner, Sara
AU - Werner, Mårten
AU - Sund, Malin
AU - Khaw, Kay Tee
AU - Wareham, Nicholas
AU - Travis, Ruth C.
AU - Norat, Teresa
AU - Wark, Petra A.
AU - Riboli, Elio
AU - Nöthlings, Ute
PY - 2013/2/1
Y1 - 2013/2/1
N2 - General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; ptrend < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13; <0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for HCC and GBC prevention in Western populations.
AB - General obesity has been positively associated with risk of liver and probably with biliary tract cancer, but little is known about abdominal obesity or weight gain during adulthood. We used multivariable Cox proportional hazard models to investigate associations between weight, body mass index, waist and hip circumference, waist-to-hip and waist-to-height ratio (WHtR), weight change during adulthood and risk of hepatocellular carcinoma (HCC), intrahepatic (IBDC) and extrahepatic bile duct system cancer [EBDSC including gallbladder cancer (GBC)] among 359,525 men and women in the European Prospective Investigation into Cancer and Nutrition study. Hepatitis B and C virus status was measured in a nested case-control subset. During a mean follow-up of 8.6 years, 177 cases of HCC, 58 cases of IBDC and 210 cases of EBDSC, including 76 cases of GBC, occurred. All anthropometric measures were positively associated with risk of HCC and GBC. WHtR showed the strongest association with HCC [relative risk (RR) comparing extreme tertiles 3.51, 95% confidence interval (95% CI): 2.09-5.87; ptrend < 0.0001] and with GBC (RR: 1.56, 95% CI: 1.12-2.16 for an increment of one unit in WHtR). Weight gain during adulthood was also positively associated with HCC when comparing extreme tertiles (RR: 2.48, 95% CI: 1.49-4.13; <0.001). No statistically significant association was observed between obesity and risk of IBDC and EBDSC. Our results provide evidence of an association between obesity, particularly abdominal obesity, and risk of HCC and GBC. Our findings support public health recommendations to reduce the prevalence of obesity and weight gain in adulthood for HCC and GBC prevention in Western populations.
KW - abdominal fat
KW - biliary tract neoplasms
KW - hepatocellular carcinoma
KW - liver neoplasms
KW - obesity
KW - weight change
UR - http://www.scopus.com/inward/record.url?scp=84870251301&partnerID=8YFLogxK
U2 - 10.1002/ijc.27645
DO - 10.1002/ijc.27645
M3 - Article
C2 - 22618881
AN - SCOPUS:84870251301
SN - 0020-7136
VL - 132
SP - 645
EP - 657
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -