A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells

Elodie Viry, Eric Battaglia, Valérie Deborde, Tobias Müller, Régis Réau, Elisabeth Davioud-Charvet, Denyse Bagrel*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Abstract

A phosphine-coordinated gold(I) thio-sugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells. (Chemical Equation Presented).

Original languageEnglish
Pages (from-to)1667-1670
Number of pages4
JournalChemMedChem
Volume3
Issue number11
DOIs
Publication statusPublished - 17 Nov 2008
Externally publishedYes

Keywords

  • Antitumor agents
  • Gold
  • Inhibitors
  • Oxidoreductases
  • Thioredoxin reductase

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