A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells

Elodie Viry; Eric Battaglia; Valérie Deborde; Tobias Müller; Régis Réau; Elisabeth Davioud-Charvet; Denyse Bagrel

doi:10.1002/cmdc.200800210

A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells

Elodie Viry, Eric Battaglia, Valérie Deborde, Tobias Müller, Régis Réau, Elisabeth Davioud-Charvet, Denyse Bagrel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

A phosphine-coordinated gold(I) thio-sugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells. (Chemical Equation Presented).

Original language	English
Pages (from-to)	1667-1670
Number of pages	4
Journal	ChemMedChem
Volume	3
Issue number	11
DOIs	https://doi.org/10.1002/cmdc.200800210
Publication status	Published - 17 Nov 2008
Externally published	Yes

Keywords

Antitumor agents
Gold
Inhibitors
Oxidoreductases
Thioredoxin reductase

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10.1002/cmdc.200800210

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title = "A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells",

abstract = "A phosphine-coordinated gold(I) thio-sugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells. (Chemical Equation Presented).",

keywords = "Antitumor agents, Gold, Inhibitors, Oxidoreductases, Thioredoxin reductase",

author = "Elodie Viry and Eric Battaglia and Val{\'e}rie Deborde and Tobias M{\"u}ller and R{\'e}gis R{\'e}au and Elisabeth Davioud-Charvet and Denyse Bagrel",

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AU - Viry, Elodie

AU - Battaglia, Eric

AU - Deborde, Valérie

AU - Müller, Tobias

AU - Réau, Régis

AU - Davioud-Charvet, Elisabeth

AU - Bagrel, Denyse

PY - 2008/11/17

Y1 - 2008/11/17

N2 - A phosphine-coordinated gold(I) thio-sugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells. (Chemical Equation Presented).

AB - A phosphine-coordinated gold(I) thio-sugar complex was found to exert potent cytotoxic and antiproliferative effects through thioredoxin reductase inhibition in MCF-7 cells. (Chemical Equation Presented).

KW - Antitumor agents

KW - Gold

KW - Inhibitors

KW - Oxidoreductases

KW - Thioredoxin reductase

UR - http://www.scopus.com/inward/record.url?scp=55949104654&partnerID=8YFLogxK

U2 - 10.1002/cmdc.200800210

DO - 10.1002/cmdc.200800210

M3 - Article

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AN - SCOPUS:55949104654

SN - 1860-7179

VL - 3

SP - 1667

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JO - ChemMedChem

JF - ChemMedChem

IS - 11

ER -

A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells

Abstract

Keywords

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