A Roadmap for the Success of Oncolytic Parvovirus-Based Anticancer Therapies

Anna Hartley, Gayatri Kavishwar, Ilaria Salvato, Antonio Marchini

    Research output: Contribution to journalReview articlepeer-review

    22 Citations (Scopus)

    Abstract

    Autonomous rodent protoparvoviruses (PVs) are promising anticancer agents due to their excellent safety profile, natural oncotropism, and oncosuppressive activities. Viral infection can trigger immunogenic cell death, activating the immune system against the tumor. However, the efficacy of this treatment in recent clinical trials is moderate compared with results seen in preclinical work. Various strategies have been employed to improve the anticancer activities of oncolytic PVs, including development of second-generation parvoviruses with enhanced oncolytic and immunostimulatory activities and rational combination of PVs with other therapies. Understanding the cellular factors involved in the PV life cycle is another important area of investigation. Indeed, these studies may lead to the identification of biomarkers that would allow a more personalized use of PV-based therapies. This review focuses on this work and the challenges that still need to be overcome to move PVs forward into clinical practice as an effective therapeutic option for cancer patients.

    Original languageEnglish
    Pages (from-to)537-557
    Number of pages21
    JournalAnnual Review of Virology
    Volume7
    DOIs
    Publication statusPublished - 2020

    Keywords

    • H-1PV
    • cancer therapy
    • combination therapy
    • oncolytic parvovirus
    • oncolytic virus
    • second-generation parvoviruses

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