A note regarding meta-Analysis of sequential trials with stopping for efficacy

Stephen Senn

doi:10.1002/pst.1639

A note regarding meta-Analysis of sequential trials with stopping for efficacy

Stephen Senn^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

It is shown that fixed-effect meta-Analyses of naïve treatment estimates from sequentially run trials with the possibility of stopping for efficacy based on a single interim look are unbiassed (or at the very least consistent, depending on the point of view) provided that the trials are weighted by information provided. A simple proof of this is given. An argument is given suggesting that this also applies in the case of multiple looks. The implications for this are discussed.

Original language	English
Pages (from-to)	371-375
Number of pages	5
Journal	Pharmaceutical Statistics
Volume	13
Issue number	6
DOIs	https://doi.org/10.1002/pst.1639
Publication status	Published - 1 Nov 2014

Keywords

Consistency
Fixed effects
Information
Meta-Analysis
Sequential analysis
Weighting

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10.1002/pst.1639

Cite this

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abstract = "It is shown that fixed-effect meta-Analyses of na{\"i}ve treatment estimates from sequentially run trials with the possibility of stopping for efficacy based on a single interim look are unbiassed (or at the very least consistent, depending on the point of view) provided that the trials are weighted by information provided. A simple proof of this is given. An argument is given suggesting that this also applies in the case of multiple looks. The implications for this are discussed.",

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KW - Information

KW - Meta-Analysis

KW - Sequential analysis

KW - Weighting

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A note regarding meta-Analysis of sequential trials with stopping for efficacy

Abstract

Keywords

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