A new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge Sarcotragus spinosulus

Charline Abed, Nathalie Legrave, Maeva Dufies, Guillaume Robert, Vincent Guérineau, Jean Vacelet, Patrick Auberger, Philippe Amade, Mohamed Mehiri*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

Original languageEnglish
Pages (from-to)1210-1219
Number of pages10
JournalMarine Drugs
Volume9
Issue number7
DOIs
Publication statusPublished - Jul 2011
Externally publishedYes

Keywords

  • Bioactivity
  • Hydroxylated polyprenylhydroquinone
  • Marine natural products
  • Sarcotragus spinosulus
  • Sponges

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