A new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge Sarcotragus spinosulus

Charline Abed; Nathalie Legrave; Maeva Dufies; Guillaume Robert; Vincent Guérineau; Jean Vacelet; Patrick Auberger; Philippe Amade; Mohamed Mehiri

doi:10.3390/md9071210

A new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge Sarcotragus spinosulus

Charline Abed, Nathalie Legrave, Maeva Dufies, Guillaume Robert, Vincent Guérineau, Jean Vacelet, Patrick Auberger, Philippe Amade, Mohamed Mehiri^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

20 Citations (Scopus)

Abstract

Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

Original language	English
Pages (from-to)	1210-1219
Number of pages	10
Journal	Marine Drugs
Volume	9
Issue number	7
DOIs	https://doi.org/10.3390/md9071210
Publication status	Published - Jul 2011
Externally published	Yes

Keywords

Bioactivity
Hydroxylated polyprenylhydroquinone
Marine natural products
Sarcotragus spinosulus
Sponges

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10.3390/md9071210

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abstract = "Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.",

keywords = "Bioactivity, Hydroxylated polyprenylhydroquinone, Marine natural products, Sarcotragus spinosulus, Sponges",

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year = "2011",

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T1 - A new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge Sarcotragus spinosulus

AU - Abed, Charline

AU - Legrave, Nathalie

AU - Dufies, Maeva

AU - Robert, Guillaume

AU - Guérineau, Vincent

AU - Vacelet, Jean

AU - Auberger, Patrick

AU - Amade, Philippe

AU - Mehiri, Mohamed

PY - 2011/7

Y1 - 2011/7

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AB - Chemical investigation of the Mediterranean sponge Sarcotragus spinosulus led to the isolation of a new hydroxylated nonaprenylhydroquinone, along with two known metabolites, hepta- and octaprenylhydroquinones. The structure of the new metabolite was assigned by extensive 1D and 2D NMR analyses and MS studies. The antileukemic effect of the three compounds towards the chronic myelogenous leukemia (CML) cells line K562 was also evaluated.

KW - Bioactivity

KW - Hydroxylated polyprenylhydroquinone

KW - Marine natural products

KW - Sarcotragus spinosulus

KW - Sponges

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SN - 1660-3397

VL - 9

SP - 1210

EP - 1219

JO - Marine Drugs

JF - Marine Drugs

IS - 7

ER -

A new hydroxylated nonaprenylhydroquinone from the mediterranean marine sponge Sarcotragus spinosulus

Abstract

Keywords

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