A Hot Topic: Cancer Immunotherapy and Natural Killer Cells

Tatiana Michel, Markus Ollert, Jacques Zimmer*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)


Despite significant progress in recent years, the therapeutic approach of the multiple different forms of human cancer often remains a challenge. Besides the well-established cancer surgery, radiotherapy and chemotherapy, immunotherapeutic strategies gain more and more attention, and some of them have already been successfully introduced into the clinic. Among these, immunotherapy based on natural killer (NK) cells is considered as one of the most promising options. In the present review, we will expose the different possibilities NK cells offer in this context, compare data about the theoretical background and mechanism(s) of action, report some results of clinical trials and identify several very recent trends. The pharmaceutical industry is quite interested in NK cell immunotherapy, which will benefit the speed of progress in the field
Original languageEnglish
Article number797
JournalInternational Journal of Molecular Sciences
Issue number2
Publication statusPublished - 12 Jan 2022


  • Cancer
  • Immunotherapy
  • Natural killer cells


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