A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

Snehaa V Seal; Mathilde Henry; Clémentine Pajot; Cyrielle Holuka; Danielle Bailbé; Jamileh Movassat; Muriel Darnaudéry; Jonathan D Turner

doi:10.3389/fimmu.2022.896179

A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

Snehaa V Seal, Mathilde Henry, Clémentine Pajot, Cyrielle Holuka, Danielle Bailbé, Jamileh Movassat, Muriel Darnaudéry, Jonathan D Turner^*

^*Corresponding author for this work

Immune Endocrine and Epigenetics

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.

Original language	English
Article number	896179
Journal	Frontiers in Immunology
Volume	13
DOIs	https://doi.org/10.3389/fimmu.2022.896179
Publication status	Published - 23 May 2022

Keywords

cytokines
diabetes
Goto-Kakizaki rats
inflammation
microarrays
obesity

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10.3389/fimmu.2022.896179Licence: CC BY

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title = "A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes",

abstract = "Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.",

keywords = "cytokines, diabetes, Goto-Kakizaki rats, inflammation, microarrays, obesity",

author = "Seal, {Snehaa V} and Mathilde Henry and Cl{\'e}mentine Pajot and Cyrielle Holuka and Danielle Bailb{\'e} and Jamileh Movassat and Muriel Darnaud{\'e}ry and Turner, {Jonathan D}",

note = "Funding Information: This work was funded by French National Research Agency (ANR-17-CE37-0020, Maternal diabetes and neuropsychiatric vulnerability in offspring: role of DNA methylation -MADAM) and by Fonds National de Recherche Luxembourg (INTER/ANR/16/11568350 {\textquoteleft}MADAM{\textquoteright}) and (Age Acceleration through the life course (C19/SC/13650569 {\textquoteleft}ALAC{\textquoteright}). This work was supported by the University of Bordeaux and by the AlimH department of the Institut National de la Recherche Agronomique (INRAE). Publisher Copyright: Copyright {\textcopyright} 2022 Seal, Henry, Pajot, Holuka, Bailb{\'e}, Movassat, Darnaud{\'e}ry and Turner.",

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doi = "10.3389/fimmu.2022.896179",

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AU - Seal, Snehaa V

AU - Henry, Mathilde

AU - Pajot, Clémentine

AU - Holuka, Cyrielle

AU - Bailbé, Danielle

AU - Movassat, Jamileh

AU - Darnaudéry, Muriel

AU - Turner, Jonathan D

N1 - Funding Information: This work was funded by French National Research Agency (ANR-17-CE37-0020, Maternal diabetes and neuropsychiatric vulnerability in offspring: role of DNA methylation -MADAM) and by Fonds National de Recherche Luxembourg (INTER/ANR/16/11568350 ‘MADAM’) and (Age Acceleration through the life course (C19/SC/13650569 ‘ALAC’). This work was supported by the University of Bordeaux and by the AlimH department of the Institut National de la Recherche Agronomique (INRAE). Publisher Copyright: Copyright © 2022 Seal, Henry, Pajot, Holuka, Bailbé, Movassat, Darnaudéry and Turner.

PY - 2022/5/23

Y1 - 2022/5/23

N2 - Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.

AB - Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.

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KW - Goto-Kakizaki rats

KW - inflammation

KW - microarrays

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A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

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Keywords

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