A HELLP syndrome complicates a gestational trophoblastic neoplasia in a perimenopausal woman: A case report

Guillaume Vogin*, François Golfier, Touria Hajri, Agnès Leroux, Béatrice Weber

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Abstract

Background: HELLP syndrome is a combination of symptoms described as hemolysis, elevated liver enzymes and low platelets, that complicates 0.01-0.6 % of pregnancies. HELLP syndrome has been scarcely reported associated with partial moles, another rare complication of pregnancy. This manuscript describes the only reported case of HELLP syndrome associated with a complete invasive hydatiform mole. Case presentation: We report a perimenopausal patient in prolonged remission from an uncommon high-risk invasive complete mole. The diagnosis was set in a context of early onset preeclampsia and HELLP syndrome. The development of life-threatening complications required primary hysterectomy. Postoperative hCG quickly returned to normal with EMA/CO multi-agent chemotherapy. Conclusion: Our patient is in prolonged remission from a complete mole complicated with EOP and HELLP syndrome. This exceptional case of complicated gestational trophoblastic neoplasia reflects a very rare condition in which several risk factors for placental ischemia are associated. Emergency hysterectomy should be considered as salvage initial treatment in such life-threatening situations.

Original languageEnglish
Article number573
JournalBMC Cancer
Volume16
Issue number1
DOIs
Publication statusPublished - 2 Aug 2016
Externally publishedYes

Keywords

  • Gestational trophoblastic neoplasia
  • HELLP syndrome
  • Perimenopause
  • Preeclampsia

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