A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies

André Zelanis; Débora A. Silva; Eduardo S. Kitano; Tarcísio Liberato; Isabella Fukushima; Solange M.T. Serrano; Alexandre K. Tashima

doi:10.1016/j.cbd.2019.100599

A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies

André Zelanis^*
, Débora A. Silva
, Eduardo S. Kitano
, Tarcísio Liberato
, Isabella Fukushima
, Solange M.T. Serrano
, Alexandre K. Tashima

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Snake venoms are complex mixtures of a large number of distinct proteins and peptides with biological activity. Peptide spectral libraries are compilations of previously identified MS/MS spectra obtained from proteomics experiments. Here we present the generation and use of a Venom Peptidome and a Venom Proteome spectral library for the analysis of venom proteomes and peptidomes from distinct snake species.

Original language	English
Article number	100599
Journal	Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics
Volume	31
DOIs	https://doi.org/10.1016/j.cbd.2019.100599
Publication status	Published - Sept 2019
Externally published	Yes

Keywords

Database searching
Peptidome
Proteome
Snake venom
Spectral libraries

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10.1016/j.cbd.2019.100599

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title = "A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies",

abstract = "Snake venoms are complex mixtures of a large number of distinct proteins and peptides with biological activity. Peptide spectral libraries are compilations of previously identified MS/MS spectra obtained from proteomics experiments. Here we present the generation and use of a Venom Peptidome and a Venom Proteome spectral library for the analysis of venom proteomes and peptidomes from distinct snake species.",

keywords = "Database searching, Peptidome, Proteome, Snake venom, Spectral libraries",

author = "Andr{\'e} Zelanis and Silva, \{D{\'e}bora A.\} and Kitano, \{Eduardo S.\} and Tarc{\'i}sio Liberato and Isabella Fukushima and Serrano, \{Solange M.T.\} and Tashima, \{Alexandre K.\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Inc.",

year = "2019",

month = sep,

doi = "10.1016/j.cbd.2019.100599",

language = "English",

volume = "31",

journal = "Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics",

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publisher = "Elsevier Inc.",

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T1 - A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies

AU - Zelanis, André

AU - Silva, Débora A.

AU - Kitano, Eduardo S.

AU - Liberato, Tarcísio

AU - Fukushima, Isabella

AU - Serrano, Solange M.T.

AU - Tashima, Alexandre K.

PY - 2019/9

Y1 - 2019/9

N2 - Snake venoms are complex mixtures of a large number of distinct proteins and peptides with biological activity. Peptide spectral libraries are compilations of previously identified MS/MS spectra obtained from proteomics experiments. Here we present the generation and use of a Venom Peptidome and a Venom Proteome spectral library for the analysis of venom proteomes and peptidomes from distinct snake species.

AB - Snake venoms are complex mixtures of a large number of distinct proteins and peptides with biological activity. Peptide spectral libraries are compilations of previously identified MS/MS spectra obtained from proteomics experiments. Here we present the generation and use of a Venom Peptidome and a Venom Proteome spectral library for the analysis of venom proteomes and peptidomes from distinct snake species.

KW - Database searching

KW - Peptidome

KW - Proteome

KW - Snake venom

KW - Spectral libraries

UR - https://www.scopus.com/pages/publications/85066853389

U2 - 10.1016/j.cbd.2019.100599

DO - 10.1016/j.cbd.2019.100599

M3 - Article

C2 - 31181499

AN - SCOPUS:85066853389

SN - 1744-117X

VL - 31

JO - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics

JF - Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics

M1 - 100599

ER -

A first step towards building spectral libraries as complementary tools for snake venom proteome/peptidome studies

Abstract

Keywords

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