A European multicenter association study of HTR2A receptor polymorphism in bipolar affective disorder

Isabelle Massat*, Daniel Souery, Olivier Lipp, Sylvie Blairy, Georgie Papadimitriou, Dimitri Dikeos, Manfred Ackenheil, Sybille Fuchshuber, Christiane Hilger, Radka Kaneva, Vibra Milanova, Geert Verheyen, Peter Raeymaekers, Luc Staner, Lilijana Oruc, M. Jakovljevic, Alessandro Serretti, Fabio Macciardi, Christine Van Broeckhoven, Julien Mendlewicz

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Abstract

The available data on the role of 5-HT in a variety of behaviors support the hypothesis that a dysfunction in brain serotoninergic system activity contributes to vulnerability to major depression. The diversity in the electrophysiological actions of 5-HT in the central nervous system can now be categorized according to receptor subtypes and their respective effector mechanisms. In particular, the implication of central postsynaptic 5-HT2A receptor in affective disorders has been supported by findings consistent with the hypothesis of 5-HT2A receptor up-regulation in depression. For these reasons, the 5-HT2A receptor (HTR2A) gene can be considered as a candidate gene in bipolar affective disorder (BPAD). We tested the possible genetic contribution of the polymorphic DNA variation T102C in exon 1 of HTR2A (chromosome 13q14-21) gene in a large European multicentric case-control sample. Allele and genotype frequencies, as well as homo-heterozygote distributions were compared between the two groups of 309 bipolar affective disorder patients and 309 matched controls. No significant differences were observed in the allelic and genotypic (also for homo-heterozygote) distribution between BPAD and controls. These results indicate that, in our sample, the 5-HT2A receptor polymorphism studied is unlikely to play a major role in the genetic susceptibility to BPAD. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)136-140
Number of pages5
JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Volume96
Issue number2
DOIs
Publication statusPublished - 3 Apr 2000

Keywords

  • 5-HT2A receptor
  • Association study, bipolar affective disorder
  • Candidate gene
  • HTR2A

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