A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

Longfei Mao; Averina Nicolae; Miguel A.P. Oliveira; Feng He; Siham Hachi; Ronan M.T. Fleming

doi:10.1016/j.csbj.2015.08.002

A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

Longfei Mao, Averina Nicolae, Miguel A.P. Oliveira, Feng He, Siham Hachi, Ronan M.T. Fleming^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.

Original language	English
Pages (from-to)	484-491
Number of pages	8
Journal	Computational and Structural Biotechnology Journal
Volume	13
DOIs	https://doi.org/10.1016/j.csbj.2015.08.002
Publication status	Published - 2015

Keywords

Constraint-based modelling
Dopaminergic neurons
Energy metabolism
Metabolic reconstruction
Parkinson's disease

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10.1016/j.csbj.2015.08.002

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title = "A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease",

abstract = "One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.",

keywords = "Constraint-based modelling, Dopaminergic neurons, Energy metabolism, Metabolic reconstruction, Parkinson's disease",

author = "Longfei Mao and Averina Nicolae and Oliveira, {Miguel A.P.} and Feng He and Siham Hachi and Fleming, {Ronan M.T.}",

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language = "English",

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T1 - A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

AU - Mao, Longfei

AU - Nicolae, Averina

AU - Oliveira, Miguel A.P.

AU - He, Feng

AU - Hachi, Siham

AU - Fleming, Ronan M.T.

PY - 2015

Y1 - 2015

N2 - One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.

AB - One of the hallmarks of sporadic Parkinson's disease is degeneration of dopaminergic neurons in the pars compacta of the substantia nigra. The aetiopathogenesis of this degeneration is still not fully understood, with dysfunction of many biochemical pathways in different subsystems suggested to be involved. Recent advances in constraint-based modelling approaches hold great potential to systematically examine the relative contribution of dysfunction in disparate pathways to dopaminergic neuronal degeneration, but few studies have employed these methods in Parkinson's disease research. Therefore, this review outlines a framework for future constraint-based modelling of dopaminergic neuronal metabolism to decipher the multi-factorial mechanisms underlying the neuronal pathology of Parkinson's disease.

KW - Constraint-based modelling

KW - Dopaminergic neurons

KW - Energy metabolism

KW - Metabolic reconstruction

KW - Parkinson's disease

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DO - 10.1016/j.csbj.2015.08.002

M3 - Review article

AN - SCOPUS:84948775784

SN - 2001-0370

VL - 13

SP - 484

EP - 491

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -

A constraint-based modelling approach to metabolic dysfunction in Parkinson's disease

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Keywords

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