A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Alexander Mazein; Steven Watterson; Wei Yuan Hsieh; William J. Griffiths; Peter Ghazal

doi:10.1016/j.bcp.2013.03.021

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Alexander Mazein
, Steven Watterson
, Wei Yuan Hsieh
, William J. Griffiths
, Peter Ghazal^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

71 Citations (Scopus)

Abstract

Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

Original language	English
Pages (from-to)	56-66
Number of pages	11
Journal	Biochemical Pharmacology
Volume	86
Issue number	1
DOIs	https://doi.org/10.1016/j.bcp.2013.03.021
Publication status	Published - 2013
Externally published	Yes

Keywords

Cholesterol
Metabolic network
Pathway map
SBGN
Sterol

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10.1016/j.bcp.2013.03.021

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title = "A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway",

abstract = "Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.",

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AU - Mazein, Alexander

AU - Watterson, Steven

AU - Hsieh, Wei Yuan

AU - Griffiths, William J.

AU - Ghazal, Peter

PY - 2013

Y1 - 2013

N2 - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

AB - Cholesterol biosynthesis serves as a central metabolic hub for numerous biological processes in health and disease. A detailed, integrative single-view description of how the cholesterol pathway is structured and how it interacts with other pathway systems is lacking in the existing literature. Here we provide a systematic review of the existing literature and present a detailed pathway diagram that describes the cholesterol biosynthesis pathway (the mevalonate, the Kandutch-Russell and the Bloch pathway) and shunt pathway that leads to 24(S),25-epoxycholesterol synthesis. The diagram has been produced using the Systems Biology Graphical Notation (SBGN) and is available in the SBGN-ML format, a human readable and machine semantically parsable open community file format.

KW - Cholesterol

KW - Metabolic network

KW - Pathway map

KW - SBGN

KW - Sterol

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DO - 10.1016/j.bcp.2013.03.021

M3 - Article

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SN - 0006-2952

VL - 86

SP - 56

EP - 66

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

IS - 1

ER -

A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway

Abstract

Keywords

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