A beginner's guide to NF-κB signaling pathways

Sylvie Delhalle, Romain Blasius, Mario Dicato, Marc Diederich*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

93 Citations (Scopus)

Abstract

Nuclear factor κB (NF-κB) belongs to a family of heterodimeric transcription factors that play a key role in inflammatory and stress responses as well as in tumor cell resistance to apoptosis. These effects are due to the NF-κB-dependent transcription of many proinflammatory and antiapoptotic genes, whose products ensure various cell responses to environmental conditions. The signal transduction pathways leading to NF-κB activation are well characterized, and the different steps implicated in these pathways involve proteins that could constitute targets for NF-κB inhibition. Several inhibitors aiming to prevent NF-κB activity and thus the transcription of target genes are studied, and a few compounds seem particularly promising. We try here to summarize the advantages that can issue from various studies on NF-κB.

Original languageEnglish
Pages (from-to)1-13
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1030
DOIs
Publication statusPublished - 2004
Externally publishedYes

Keywords

  • Apoptosis
  • Cancer
  • Inflammation
  • NF-κB

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