5-HT2a receptor polymorphism gene in bipolar disorder and harm avoidance personality trait

Sylvie Blairy*, I. Massat, L. Staner, O. Le Bon, S. Van Gestel, C. Van Broeckhoven, C. Hilger, F. Hentges, D. Souery, J. Mendlewicz

*Corresponding author for this work

    Research output: Contribution to journalArticleResearchpeer-review

    67 Citations (Scopus)

    Abstract

    The purpose of this study was to investigate the relationship between bipolar disorder and the harm avoidance personality trait (HA), and the genetic contribution of the polymorphic DNA variation T102C in exon 1 of 5- HTR2a (chromosome 13q14-21) in bipolar disorder and HA personality trait. Forty bipolar patients and 89 normal subjects completed the TPQ questionnaire and were genotyped for 5-HT2a. Bipolar patients scored higher than normal subjects on the HA dimension. However, no contribution of the 5-HTR2a polymorphism on the bipolar disorder or on the HA personality trait emerged. Despite the limited sample size, these results exclude a major effect of the 5-HTR2a polymorphism on bipolar disorder and HA personality trait but not a minor effect. (C) 2000 Wiley-Liss, Inc.

    Original languageEnglish
    Pages (from-to)360-364
    Number of pages5
    JournalAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
    Volume96
    Issue number3
    DOIs
    Publication statusPublished - 12 Jun 2000

    Keywords

    • 5-HT2A
    • Association study
    • Bipolar disorder
    • Harm avoidance
    • Personality

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