Abstract
Objective: To compare the 2D and 3D MOCART system obtained with 9.4T high-field magnetic resonance imaging (MRI) for the exvivo analysis of osteochondral repair in a translational model and to correlate the data with semiquantitative histological analysis. Methods: Osteochondral samples representing all levels of repair (sheep medial femoral condyles; n=38) were scanned in a 9.4T high-field MRI. The 2D and adapted 3D MOCART systems were used for grading after point allocation to each category. Each score was correlated with corresponding reconstructions between both MOCART systems. Data were next correlated with corresponding categories of an elementary (Wakitani) and a complex (Sellers) histological scoring system as gold standards. Results: Correlations between most 2D and 3D MOCART score categories were high, while mean total point values of 3D MOCART scores tended to be 15.8-16.1 points higher compared to the 2D MOCART scores based on a Bland-Altman analysis. "Defect fill" and "total points" of both MOCART scores correlated with corresponding categories of Wakitani and Sellers scores (all P≤0.05). "Subchondral bone plate" also correlated between 3D MOCART and Sellers scores (. P<0.001). Conclusions: Most categories of the 2D and 3D MOCART systems correlate, while total scores were generally higher using the 3D MOCART system. Structural categories "total points" and "defect fill" can reliably be assessed by 9.4T MRI evaluation using either system, "subchondral bone plate" using the 3D MOCART score. High-field MRI is valuable to objectively evaluate osteochondral repair in translational settings.
Original language | English |
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Pages (from-to) | 1386-1395 |
Number of pages | 10 |
Journal | Osteoarthritis and Cartilage |
Volume | 22 |
Issue number | 10 |
DOIs | |
Publication status | Published - 1 Oct 2014 |
Externally published | Yes |
Keywords
- Cartilage repair
- Correlation
- Histological analysis
- MRI
- Osteochondral unit
- Sheep