Abstract
The regioselective lithiation of dithienothiazines followed by electrophilic trapping in a one-pot fashion is an efficient route to 2-mono- and 2,6-difunctionalized dithienothiazines. A pseudo five-component dilithiation-diformylation-double-Wittig olefination sequence gives a dithienothiazine symmetrically functionalized with α,β-unsaturated ester side chains in excellent yield.
Original language | English |
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Article number | ST-2013-B0975-L |
Pages (from-to) | 371-374 |
Number of pages | 4 |
Journal | Synlett |
Volume | 25 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 2014 |
Externally published | Yes |
Keywords
- Wittig reactions
- addition reactions
- heterocycles
- lithiation
- multicomponent reactions