2,6-difunctionalization of N-substituted dithienothiazines via dilithiation

Catherine Dostert, Daniel Czajkowski, Thomas J.J. Müller*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

The regioselective lithiation of dithienothiazines followed by electrophilic trapping in a one-pot fashion is an efficient route to 2-mono- and 2,6-difunctionalized dithienothiazines. A pseudo five-component dilithiation-diformylation-double-Wittig olefination sequence gives a dithienothiazine symmetrically functionalized with α,β-unsaturated ester side chains in excellent yield.

Original languageEnglish
Article numberST-2013-B0975-L
Pages (from-to)371-374
Number of pages4
JournalSynlett
Volume25
Issue number3
DOIs
Publication statusPublished - Feb 2014
Externally publishedYes

Keywords

  • Wittig reactions
  • addition reactions
  • heterocycles
  • lithiation
  • multicomponent reactions

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