14-3-3 protein is a component of Lewy bodies in Parkinson's disease - Mutation analysis and association studies of 14-3-3 eta

Andreas Ubl, Daniela Berg, Carsten Holzmann, Rejko Krüger, Klaus Berger, Thomas Arzberger, Antje Bornemann, Olaf Riess*

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Abstract

Mutations in α-synuclein have been identified in some rare families with autosomal dominant Parkinson's disease (PD). The synuclein gene family shares physical and functional homology with 14-3-3 proteins and binds to 14-3-3 proteins and to its ligands. We therefore investigated whether 14-3-3 proteins are also involved in the pathogenesis of PD. Here we demonstrate that 14-3-3 proteins are colocalized with Lewy bodies in PD. We investigated the 14-3-3 eta (YWHAH) gene by mutation analysis and association studies as it maps to human chromosome 22q12.1-q13.1, a region which has been recently implicated in PD and carried out immunohistochemical studies of Lewy bodies with two different 14-3-3 eta antibodies. In 358 sporadic and familial PD patients, disease causing mutations were not identified. Furthermore, association studies with intragenic polymorphisms do not provide evidence for an involvement of 14-3-3 eta in the pathogenesis of PD. In accordance with these findings, there was no staining of substantia nigra Lewy bodies with antibodies specific for the 14-3-3 eta subunit.

Original languageEnglish
Pages (from-to)33-39
Number of pages7
JournalMolecular Brain Research
Volume108
Issue number1-2
DOIs
Publication statusPublished - 16 Dec 2002
Externally publishedYes

Keywords

  • 14-3-3 eta
  • Association studies
  • Lewy body
  • Mutation analysis
  • Parkinson's disease

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