Understanding the Flexibility of 1C metabolism and its role during metastatic dissemination of cancer cell

After cardiovascular diseases, cancer represents the second biggest death causing disease. During the last years, significant improvements have been made in terms of cancer prevention, early diagnosis and treatment of primary tumours.However, when tumours start to metastasise, life expectation strongly decreases and clinical treatment options are limited. Therefore, it is very important to better understand the mechanisms of when, how and why cancer cells become metastatic.One tumour type that has a high metastatic potential is breast cancer, which also belongs to the most common cancer types. Especially, treatment resistance contributes to metastatic spread and decreased life expectancy. One factor that is instrumental for the adaptation of tumour cells to colonise different organs and to survive chemotherapy is cellular metabolism. In recent years, we have identified a metabolic pathway that provides advantage to cancer cells to such adaptation. Therefore, we will study in 1cFlex how this metabolic pathway can be targeted by therapy to prevent adaptationof cancer cells, thereby preventing tumour escape and reducing metastatic spreading. Overall, this attempt aims in improving patient health and overall surviv