Tumour plasticity as a treatment resistance mechanism in glioblastoma.

Project Details


GBM cells display strong intrinsic plasticity and adapt reversibly to changing microenvironmental stimuli, forming a dynamic ecosystem. The role of tumour plasticity in creating treatment-resistant states is currently less understood. Here we will leverage existing and novel single cell RNA-Seq datasets to investigate transcriptomic changes in treatment-naive and treated tumours. We will apply advanced computational algorithms, including reference-free deconvolution methods, to reveal treatment-resistant states, their molecular signatures and regulators.
AcronymCANBIO2 (Hamed Allahverdi)
Effective start/end date1/12/2330/11/27


  • FNR - Fonds National de la Recherche: €170,000.00


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