Role of chemokine receptor-bearing extracellular vesicles in leukaemia and lymphoma

Project Details

Description

The interactions between CXCR4 and its ligand, the chemokine CXCL12 play a prominent role in the initiation and the progression of various types of cancer, including B-cell neoplasms like chronic lymphocytic leukaemia (CLL) or diffuse large B-cell lymphoma (DLBCL). This interaction is regulated by a third partner, the atypical chemokine receptor ACKR3 (CXCR7) that acts as a scavenger receptor for CXCL12, internalizing the chemokine and regulating its local availability for CXCR4 and thereby participating in the modulation of the tumour growth, migration and invasion. The goal of the project is to investigate the role, the mechanism and the functional relevance of the newly discovered ability of ACKR3-expressing cells to massively release small extracellular vesicles (sEV) displaying high density of ACKR3 upon stimulation by CXCL12, in the regulation ofthe CXCL12-CXCR4 axis in cancer. These questions will be addressed mainly in the context of CLL and DLBCL, the most common forms of leukaemia and lymphoma in adults. Different state-of-the-art molecular, cellular approaches and in vivo models will be applied and the results will be confirmed with patient-derived samples.
AcronymEVceptor
StatusActive
Effective start/end date1/05/2230/04/24

Funding

  • FNRS - Fonds National de la Recherche Scientifique: €134,000.00

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