Project Details
Description
Receptors for entry of SARS-CoV-2 into lung pneumocytes belong to the renin-angiotensin system (RAS) anddiseases that are associated to a dysregulation of the same system (e.g.: diabetes, hypertension, and cardiovascular diseases) are thought to be associated with a bad Covid-19 prognosis. These receptors are also expressed on cells of the immune system, which is involved in diseases associated to RAS dysregulation. Our project plan to employ an integrated mass spectrometry / flow cytometry approach to build a quantitative map of the RAS, at the peptide and protein level together with a single cell analysis of the immune cells in individuals infected by the SARS-CoV-2.
The aim of the project is to use this integrated map together with data and metadata generated by running clinical trials to find correlations to Covid-19 prognosis. We expect to build a mechanistic model on how viral infection modulates the RAS, the immune system, and the expression of the receptors. Finally, we wish to find a potential biomarker for Covid-19 prognosis by a simple flow cytometric assay transferable to the clinic.
The aim of the project is to use this integrated map together with data and metadata generated by running clinical trials to find correlations to Covid-19 prognosis. We expect to build a mechanistic model on how viral infection modulates the RAS, the immune system, and the expression of the receptors. Finally, we wish to find a potential biomarker for Covid-19 prognosis by a simple flow cytometric assay transferable to the clinic.
Acronym | RAS CoV-2 |
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Status | Finished |
Effective start/end date | 1/05/20 → 28/02/21 |
Funding
- FNR - Fonds National de la Recherche: €36,000.00
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