Human antigen peptide transporter (TAP)-deficient patients suffer from chronic bacterial infections of the airways and bronchiectasis. NK cells are non-functional in TAP-KO mice and we speculate that this might increase their susceptibility to bacterial infections. However, TAP1-KO mice show no obvious phenotype under SPF conditions. We will challenge TAP-KO mice with several lung pathogensand monitor chronic colonization and development of lung lesions. A straight focus will be on the roles of NK cells and Treg cells with the aim to elucidate their functionality in the anti-bacterial immune reactions.We hypothesize that exosomes might be involved in these processes[19, 20]andthe significance of exosomes formation/function in NK cellsfor cellular communication with Treg cells, the formation of cytotoxic exosomes in the context of TAP-deficiency will be investigated.
|Acronym||NEXTIMMUNE (Neha Patil)|
|Effective start/end date||15/03/17 → 14/03/21|
- FNR - Fonds National de la Recherche: €169,500.00
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