N6 - methyladenosine RNA modification in acute coronary syndrome

Project Details


This project aims to explore if m6A modifications in circulating RNAs could be used as biomarker of clinical outcome after ACS. Furthermore, we aim to identify and functionally characterize ACS-specific m6A modifications in coding and non-coding RNAs. In order to achieve those aims, we have set the following specific research objectives:
1. To quantify total m6A modification in peripheral blood mononuclear cells (PBMCs) of ACS patients using the LC/MS method
2. To assess the biomarker potential of m6A modification
3. To identify ACS-specific m6A modifications in coding and non-coding RNAs using Nanopore sequencing
4. To perform an in vitro functional analysis of ACS-specific m6A modifications.
Effective start/end date1/03/2328/02/25


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