Molecular mechanisms of chronic inflammation connected to cancer development

Chronic inflammation is a major driver of cancer development[27, 28].However, with certain exceptions (ROS, NF-κB)the molecular mechanisms linking inflammation to cancer development remain elusive. In this project the PhD candidatewill study the role of APOBEC3A, a DNA mutator, and its role in cellular transformation. Dr. Perez Bercoff will spend a sabbatical year in the molecular retrovirology laboratory of Pr. Wain-Hobson at the Pasteur Institute in Paris in order to initiate this project before the onset of the PhD project described here, explaining why this project will start in the second phase of the DTUand we willnot describe it in more detail here.