Metabolic gatekeepers in T cells: Decision making and controlling inflammation in vivo

Inappropriate metabolic programs in activated immune cells underlie many aberrant immune responses, implying that the manipulation of the metabolism of these cells might beneficially enhance or temper immunity. Main findings:By genetic targeting of key metabolic enzymes, the candidate has identified a metabolic regulator that controls the activity of T cells. Mutant mice are more susceptible to viral infections. The altered metabolic landscape might lead to epigenetic modifications and the candidate is currently characterizing the underlying mechanisms.