Investigating the effects of microbiologicalmetabolites on the immune system

Microbial metabolites significantly influence the function and differentiation of T cells, particularly regulatory T cells (Tregs), which play a crucial role in maintaining immune homeostasis and preventing autoimmune diseases. One example are short-chain fatty acids (SCFAs), such as butyrate, propionate, and acetate, produced by gut microbiota fermentation of dietary fibres. SCFAs have been shown to enhance the differentiation and function of Tregs, thereby promoting anti-inflammatory responses. Additionally, these metabolites can modulate the expression of genes involved in Treg cell development by applying epigenetic changes such as methylation or acetylation, further underscoring their pivotal role in shaping immune response.

This project aims to identify and characterize microbial metabolites impacting Tregs, including the effects of metabolites on Treg functions and responses to immune challenges. We plan to link metabolites to their microbial origins and correlate them with immune-related diseases using database comparisons. In vivo experiments will confirm their therapeutic potential, offering new strategies for regulating the immune system and treating immune-mediated diseases.