Project Details
Description
Allergic asthma is a chronic inflammatory disease triggered by inhaled allergens and other environmental factors. In asthmatic patients, chronicity is characterized by airway inflammation and epithelial alterations. Several studies have already explored the link between immune cells and neurotrophic factors in the case of asthma and it turns out that Neurturin (NRTN), which is a member of the glial cell line-derived neurotrophic factor (GDNF) family, has beneficial effects on the inflammatory response and is involved in epithelial-mesenchymal interactions.
As NRTN receptors are expressed on several immune cells and lung epithelial cells, and respiratory and gut microbiomes are both playing a role in asthma, the objective of the project is to study the interactions between epithelial cells, immune cells and the microbiome in the context of allergic airway inflammation
As NRTN receptors are expressed on several immune cells and lung epithelial cells, and respiratory and gut microbiomes are both playing a role in asthma, the objective of the project is to study the interactions between epithelial cells, immune cells and the microbiome in the context of allergic airway inflammation
Acronym | MICROH-DTU |
---|---|
Status | Finished |
Effective start/end date | 1/01/19 → 31/12/22 |
Funding
- FNR - Fonds National de la Recherche: €164,632.00
Fingerprint
Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.