Integrative approach to identify drivers of acute immune responses in food allergy

Project Details


Food allergy is a complex pathology summarizing immune-mediated responses directed against specific foods. Predictive biomarkers of clinical key events – reaction phenotypes, disease prognosis and immunotherapy response – are evasive to date. The present study will base on a recently published work (doi: 10.1111/all.15408). Our aim is to address immune aspects underlying acute Th2-skewed inflammatory responses in order to provide insights in the pathophysiology of food allergy and inferring biomarkers being predictive for reaction patterns.
Klueber J, C.-M.F., Czolk R, Montamat G, Revets D, Konstantinou M, Cosma A, Hunewald O, Stahl Skov P, Ammerlaan W, Hilger C, Bindslev-Jensen C, Ollert M, Kuehn A, High-dimensional immune profiles correlate with phenotypes of peanut allergy during food-allergic reactions. under review.

Czolk, R., et al., IgE-Mediated Peanut Allergy: Current and Novel Predictive Biomarkers for Clinical Phenotypes Using Multi-Omics Approaches. Front Immunol, 2020. 11: p. 594350.

Kalic, T., et al., Patients Allergic to Fish Tolerate Ray Based on the Low Allergenicity of Its Parvalbumin. J Allergy Clin Immunol Pract, 2019. 7(2): p. 500-508 e11.
AcronymNextimmune-2 (Böhm Theresa-Maria)
Effective start/end date1/04/2331/03/27


  • FNR - Fonds National de la Recherche: €186,000.00


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