Harnessing DNA repair factors to promote an innate immune response against glioblastoma

Preliminary evidence from the consortium suggests that the DNA repair status of GBM cells affects the recruitment of tumour-associated macrophages (TAMs) and the mounting of an innate immune response. Here we will investigate whether DNA repair-based strategies can contribute to turn GBM into an “immunologically hot” tumour. An RNAi screen will be performed in GBM cells to identify the DNA repair factors whose depletion promotes phagocytosis by macrophages.