Elucidating the role of susceptibility pathways during bacterial-induced colitis

Protein ubiquitination has emerged as one of the key mechanisms regulating immune homeostasis[14, 15]. A molecule vital for the regulation of inflammation is the E3-ubiquitin ligase Ariadne-2 (Arih2). Arih2 has been described as a central molecule that limits inflammationand Arih2-deficient mice suffer from a lethal auto-inflammatory disease[16]. Weconditionally targeted Arih2 and used the resulting Arih2fl/flmice to generate T cell specific CD4-Cre-Arih2fl/flmice(unpublished). In this proposal we are aiming to investigate Arih2’s T cell specific function in vivoin the context of inflammatory diseases. The PhD project will focus onhow Arih2 influence different inflammatory T helper (Th) cell subsets. A better understanding of how inflammatory reactions are balanced will yield novel insights into the initiation and potential treatment of inflammatory diseases.This proposal is closely linked to the existingFNR ATTRACT project “Regulating the regulators: gateways of inflammation and lymphoma”.