Creation and validation of a new measure derived from continuous glucose monitoring systems to identify people living with type 1 diabetes at risk of hypoglycaemia insensitivity: exploitation of the SFDT1 cohort study

Hypoglycemia unawareness occurs when a person does not feel or notice the signs of hypoglycemia.

Around 40% of people with type 1 diabetes suffer from hypoglycemia unawareness, which is a major obstacle to achieving optimal diabetes control and is associated with reduced quality of life. Scores (Gold and Clarke) currently exist to assess the risk of hypoglycemia unawareness, but they are not used in routine clinical practice. A metric derived from continuous glucose monitoring (CGM) data would make it easy to identify patients at risk.

The main objective of SFDT1-IH is to create and validate a new CGM-derived metric to identify people with type 1 diabetes at risk of impaired hypoglycemia awareness based on data from the SFDT1 cohort study that could be used in clinical practice and estimated in an Ambulatory Glucose Profile (AGP) report.