Anti-Tumour Immunity: Tuning metabolic circuits in T-cells to fight cancer.

Since the advent of immune-checkpoint blockade, T-cells gained much attention in regard to their anti-cancer properties. It has also become obvious that alterations of the metabolic landscape impact T-cell functionality. Yet, an in-depth understanding of metabolic determinants that control phenotypes is only starting to arise. A recent metabolic screen (unpublished) performed in the Brenner lab has uncovered new regulators that impact the immune response of cytotoxic T-cells. These identified targets will be mechanistically characterised to understand their role in the immunological circuit. In addition to ex vivo T-cell assays, genetically engineered mouse models will be employed.