Advancing diagnosis and treatment of paediatric asthma by digital technology and deep immunophenotyping

Asthma is one of the most common chronic diseases in children, and its prevalence has been rising globally during the past thirty years, touching up to 10% of the young population. Diagnosis and treatment are hampered by the fact that it is a heterogenous inflammatory disease with distinct underlying pathophysiological mechanisms. There is a medical need for non-invasive clinically applicable biomarkers to improve patient diagnosis and care. For children undergoing inhaled corticosteroid therapy, poor administration techniques and low compliance further influence therapy success. In this project, we propose to combine biomarker research with a digital and easy to use technology monitoring administration of medication and quality of life of treated patients, aiming at an optimized and personalized medical care for children with chronic respiratory disease.