Metastasis is the primary cause of death from cancer. An early and critical step of the metastatic cascade is theacquisition by tumor cells of the ability to remodel the extracellular matrix (ECM) and migrate through the stromalenvironment and tissue barriers. At the subcellular level, this ability is associated with actin-rich, fingerlike,membrane protrusions termed invadopodia. The primary function of invadopodia is to concentrate and secretematrix metalloproteinases (MMPs) that degrade the ECM to facilitate tumor cell dissemination and cancerprogression. We recently identified an new actin-crosslinking protein, namely cysteine rich protein 2 (CRP2), whoseup-regulation closely correlates with metastatic breast cancers and adverse patient outcome. Previous functionalanalyses revealed that CRP2 plays a critical role in cell invasion and that its depletion dramatically reducesinvadopodia activity. The present follow-up project combines three specific and complementary research axeswhich together will establish that CRP2 is a critical molecular node bridging critical, apparently unrelated, pathwaysdriving breast cancer progression, and accordingly represents an innovative and promising therapeutic targ
|Effective start/end date||1/05/16 → 30/04/18|
- Fondation Cancer: €459,974.00
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