Zied Landoulsi

2025

Interpretable Machine Learning for Cross-Cohort Prediction of Motor Fluctuations in Parkinson's Disease

Krüger, R., Acharya, G., Aguayo, G., Alexandre, M., Batutu, R., Beaumont, K., Béchet, S., Berchem, G., Boussaad, I., Contesotto, G., Ferrari, A., Fritz, J., Gamio, C., Gantenbein, M., Georges, L., Giraitis, M., Graas, J., Hanff, A. M., Henry, E. & Henry, M. & 40 others, Hundt, A., Jónsdóttir, S., Klucken, J., Kofanova, O., Lambert, P., Landoulsi, Z., Lopes, A. F., Lorentz, V., Marques, T. M., Marques, G., Mcintyre, D., Mediouni, C., Mendibide, A., Menster, M., Mittelbronn, M., Mtimet, S., Munsch, M., Nehrbass, U., Nickels, S., Noor, F., Pauly, C., Pauly, L., Pavelka, L., Perquin, M., Pexaras, A., Rauschenberger, A., Remark, L., Richard, I., Roland, O., Sapienza, S., Sharify, A., Sokolowska, K., Theresine, M., Thien, H., Trouet, J., Tsurkalenko, O., Vaillant, M., Vega, C., Zelimkhanov, G. & the NCER-PD Consortium, 22 Apr 2025, (Accepted/In press) In: Movement Disorders. 14 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Penetrance of Parkinson’s disease in GBA1 carriers depends on variant severity and polygenic background

Landoulsi, Z., Zelimkhanov, G., Vega, C., Vaillant, M., Tsurkalenko, O., Trouet, J., Thien, H., Theresine, M., Sokolowska, K., Sharify, A., Sapienza, S., Roland, O., Richard, I., Remark, L., Rauschenberger, A., Pexaras, A., Perquin, M., Pavelka, L., Pauly, L. & Pauly, C. & 41 others, Noor, F., Nickels, S., Nehrbass, U., Munsch, M., Mtimet, S., Mittelbronn, M., Menster, M., Mendibide, A., Mediouni, C., Mcintyre, D., Marques, G., Marques, T. M., Lorentz, V., Lopes, A. F., Lambert, P., Kofanova, O., Klucken, J., Jónsdóttir, S., Hundt, A., Henry, M., Henry, E., Hanff, A. M., Graas, J., Giraitis, M., Georges, L., Gantenbein, M., Gamio, C., Fritz, J., Ferrari, A., De Bremaeker, N., Contesotto, G., Boussaad, I., Berchem, G., Béchet, S., Beaumont, K., Batutu, R., Alexandre, M., Aguayo, G., Acharya, G., Krüger, R. & NCER-PD Consortium, 12 Jun 2025, In: npj Parkinson's Disease. 11, 1, 8 p., 162.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2024

Dopamine Pathway and Parkinson's Risk Variants Are Associated with Levodopa-Induced Dyskinesia

Pavelka, L., Kolodkin, A., Acharya, G., Aguayo, G., Alexandre, M., Beaumont, K., Bellora, C., Berchem, G., Boussaad, I., Contesotto, G., Esteves, D., Fagherazzi, G., Ferrand, J. Y., Gantenbein, M., Giraitis, M., Graas, J., Heymann, M., Hundt, A., Jónsdóttir, S. & Klucken, J. & 36 others, Lambert, P., Landoulsi, Z., Lorentz, V., Lupu, P. C., Marques, T. M., Marques, G., Mcintyre, D., Mediouni, C., Menster, M., Mittelbronn, M., Nehrbass, U., Nickels, S., Noor, F., Ostaszewski, M., Pauly, C., Pauly, L., Pavelka, L., Perquin, M., Lima, R. R., Rauschenberger, A., Sandt, E., Sapienza, S., Schmitt, M., Sharify, A., Sokolowska, K., Thien, H., Trouet, J., Tsurkalenko, O., Vaillant, M., Valenti, M., Vega, C., Zelimkhanov, G., Ammerlaan, W., the NCER-PD Consortium, the International Parkinson's Disease Genomic Consortium & Gan-Or, Z., Oct 2024, In: Movement Disorders. 39, 10, p. 1773-1783 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

3 Citations (Scopus)

Gut microbiome is not associated with mild cognitive impairment in Parkinson’s disease

Aho, V. T. E., Landoulsi, Z., Krüger, R., Acharya, G., Aguayo, G., Alexandre, M., Ammerlaan, W., Batutu, R., Beaumont, K., Béchet, S., Berchem, G., Boussaad, I., Contesotto, G., De Bremaeker, N., Ferrari, A., Fritz, J., Gamio, C., Gantenbein, M., Georges, L. & Giraitis, M. & 42 others, Graas, J., Hanff, A. M., Henry, E., Henry, M., Hundt, A., Jónsdóttir, S., Klucken, J., Kofanova, O., Lambert, P., Lopes, A. F., Lorentz, V., Marques, T. M., Marques, G., Mcintyre, D., Mediouni, C., Mendibide, A., Menster, M., Mittelbronn, M., Mtimet, S., Munsch, M., Nehrbass, U., Nickels, S., Noor, F., Pauly, C., Pauly, L., Pavelka, L., Perquin, M., Pexaras, A., Rauschenberger, A., Remark, L., Richard, I., Roland, O., Sapienza, S., Sharify, A., Sokolowska, K., Theresine, M., Thien, H., Trouet, J., Vaillant, M., Vega, C., Zelimkhanov, G. & on behalf of the NCER-PD Consortium, 6 Apr 2024, In: npj Parkinson's Disease. 10, 1, 78.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

Integrating digital gait data with metabolomics and clinical data to predict outcomes in Parkinson’s disease

Zelimkhanov, G., Vega, C., Vaillant, M., Trouet, J., Thien, H., Theresine, M., Sokolowska, K., Sharify, A., Sapienza, S., Roland, O., Richard, I., Remark, L., Rauschenberger, A., Pexaras, A., Perquin, M., Pavelka, L., Pauly, L., Pauly, C., Noor, F. & Nickels, S. & 42 others, Nehrbass, U., Munsch, M., Mtimet, S., Mittelbronn, M., Menster, M., Mendibide, A., Mediouni, C., Mcintyre, D., Marques, G., Marques, T. M., Lorentz, V., Lopes, A. F., Landoulsi, Z., Lambert, P., Krüger, R., Kofanova, O., Klucken, J., Jónsdóttir, S., Hundt, A., Henry, M., Henry, E., Hanff, A. M., Graas, J., Giraitis, M., Georges, L., Gantenbein, M., Gamio, C., Fritz, J., Ferrari, A., De Bremaeker, N., Contesotto, G., Boussaad, I., Berchem, G., Béchet, S., Beaumont, K., Batutu, R., Ammerlaan, W., Alexandre, M., Aguayo, G., Acharya, G., on behalf of the NCER-PD Consortium & Glaab, E., 6 Sept 2024, In: npj Digital Medicine. 7, 1, p. 235 235.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

8 Citations (Scopus)

Mixed effects models but not t-tests or linear regression detect progression of apathy in Parkinson’s disease over seven years in a cohort: a comparative analysis

Hanff, A. M., Krüger, R., Acharya, G., Aguayo, G., Alexandre, M., Ammerlaan, W., Batutu, R., Beaumont, K., Béchet, S., Berchem, G., Boussaad, I., Contesotto, G., de Bremaeker, N., Ferrari, A., Fritz, J., Gamio, C., Gantenbein, M., georges, L., Giraitis, M. & Graas, J. & 41 others, Henry, E., Henry, M., Hundt, A., Jónsdóttir, S., Klucken, J., Kofanova, O., Lambert, P., Landoulsi, Z., Lopes, A. F., Lorentz, V., Marques, T. M., Marques, G., Mcintyre, D., Mediouni, C., Mendibide, A., Menster, M., Mittelbronn, M., Mtimet, S., Munsch, M., Nehrbass, U., Nickels, S., Noor, F., Pauly, C., Pauly, L., Pavelka, L., Perquin, M., Pexaras, A., Rauschenberger, A., Remark, L., Richard, I., Roland, O., Sapienza, S., Sharify, A., Sokolowska, K., Theresine, M., Thien, H., Trouet, J., Vaillant, M., Vega, C., Zelimkhanov, G. & on behalf of NCER-PD, 24 Aug 2024, In: BMC Medical Research Methodology. 24, 1, 183.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2 Citations (Scopus)

2023

Genetic landscape of Parkinson’s disease and related diseases in Luxembourg

Landoulsi, Z., Pachchek, S., Bobbili, D. R., Pavelka, L., May, P. & Krüger, R., 20 Dec 2023, In: Frontiers in Aging Neuroscience. 15, 14 p., 1282174.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)

GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture

Stevelink, R., Campbell, C., Chen, S., Abou-Khalil, B., Adesoji, O. M., Afawi, Z., Amadori, E., Anderson, A., Anderson, J., Andrade, D. M., Annesi, G., Auce, P., Avbersek, A., Bahlo, M., Baker, M. D., Balagura, G., Balestrini, S., Barba, C., Barboza, K. & Bartolomei, F. & 31 others, Bast, T., Baum, L., Baumgartner, T., Baykan, B., Bebek, N., Becker, A. J., Becker, F., Bennett, C. A., Berghuis, B., Berkovic, S. F., Beydoun, A., Bianchini, C., Bisulli, F., Blatt, I., Bobbili, D. R., Borggraefe, I., Bosselmann, C., Braatz, V., Bradfield, J. P., Brockmann, K., Brody, L. C., Buono, R. J., Busch, R. M., Caglayan, H., Campbell, E., Canafoglia, L., Canavati, C., Cascino, G. D., Castellotti, B., Landoulsi, Z. & International League Against Epilepsy Consortium on Complex Epilepsies, Sept 2023, In: Nature Genetics. 55, 9, p. 1471-1482 12 p.

Research output: Contribution to journal › Article › Research › peer-review

77 Citations (Scopus)

2022

Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state

Smajic, S., Prada-Medina, C. A., Landoulsi, Z., Ghelfi, J., Delcambre, S., Dietrich, C., Jarazo, J., Henck, J., Balachandran, S., Pachchek, S., Morris, C. M., Antony, P., Timmermann, B., Sauer, S., Pereira, S. L., Schwamborn, J. C., May, P., Grunewald, A. & Spielmann, M., 1 Mar 2022, In: Brain. 145, 3, p. 964-978 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

273 Citations (Scopus)

2021

Cross pharmacological, biochemical and computational studies of a human kv3.1b inhibitor from androctonus australis venom

Maatoug, S., Cheikh, A., Khamessi, O., Tabka, H., Landoulsi, Z., Guigonis, J. M., Diochot, S., Bendahhou, S. & Benkhalifa, R., 1 Nov 2021, In: International Journal of Molecular Sciences. 22, 22, 12290.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2020

Identification of a CDH12 potential candidate genetic variant for an autosomal dominant form of transgrediens and progrediens palmoplantar keratoderma in a Tunisian family

Charfeddine, C., Dallali, H., Abdessalem, G., Ghedira, K., Hamdi, Y., Elouej, S., Landoulsi, Z., Delague, V., Lagarde, A., Levy, N., El-Amraoui, A., Boubaker, M. S., Abdelhak, S. & Mokni, M., 1 Apr 2020, In: Journal of Human Genetics. 65, 4, p. 397-410 14 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

2018

Clinical and genetic study of Tunisian families with genetic generalized epilepsy: contribution of CACNA1H and MAST4 genes

Landoulsi, Z., Laatar, F., Noé, E., Mrabet, S., Ben Djebara, M., Achaz, G., Nava, C., Baulac, S., Kacem, I., Gargouri-Berrechid, A., Gouider, R. & Leguern, E., 1 Aug 2018, In: Neurogenetics. 19, 3, p. 165-178 14 p.

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Distal renal tubular acidosis in a Libyan patient: Evidence for digenic inheritance

Nagara, M., Papagregoriou, G., Ben Abdallah, R., Landoulsi, Z., Bouyacoub, Y., Elouej, S., Kefi, R., Pippucci, T., Voskarides, K., Bashamboo, A., McElreavey, K., Hachicha, M., Romeo, G., Seri, M., Deltas, C. & Abdelhak, S., Jan 2018, In: European Journal of Medical Genetics. 61, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Genetic Analysis of TREM2 Variants in Tunisian Patients with Alzheimer's Disease

Landoulsi, Z., Ben Djebara, M., Kacem, I., Sidhom, Y., Kefi, R., Abdelhak, S., Gargouri-Berrechid, A. & Gouider, R., 1 Sept 2018, In: Medical Principles and Practice. 27, 4, p. 317-322 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)

LRRK2 G2019S Parkinson's disease with more benign phenotype than idiopathic

Ben Romdhan, S., Farhat, N., Nasri, A., Lesage, S., Hdiji, O., Ben Djebara, M., Landoulsi, Z., Stevanin, G., Brice, A., Damak, M., Gouider, R. & Mhiri, C., Nov 2018, In: Acta Neurologica Scandinavica. 138, 5, p. 425-431 7 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

20 Citations (Scopus)

2017

Using KASP technique to screen LRRK2 G2019S mutation in a large Tunisian cohort

Landoulsi, Z., Benromdhan, S., Ben Djebara, M., Damak, M., Dallali, H., Kefi, R., Abdelhak, S., Gargouri-Berrechid, A., Mhiri, C. & Gouider, R., 6 Jul 2017, In: BMC Medical Genetics. 18, 1, 70.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

22 Citations (Scopus)

2016

Clinical and molecular investigation of Buschke-Fischer-Brauer in consanguineous Tunisian families

Charfeddine, C., Ktaifi, C., Laroussi, N., Hammami, H., Jmel, H., Landoulsi, Z., Badri, T., Benmously, R., Bchetnia, M., Boubaker, M. S., Fenniche, S., Abdelhak, S. & Mokni, M., 1 Dec 2016, In: Journal of the European Academy of Dermatology and Venereology. 30, 12, p. 2122-2130 9 p.

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

2014

Erratum: Inhibition of human Kv3.1 current expressed in Xenopus oocytes by the toxic venom fraction of Androctonus australis hector (Archives of Pharmacal Research DOI 10.1007/s12272-013-0176-5)

Cheikh, A., Benkhalifa, R., Landoulsi, Z., Chatti, I. & El Ayeb, M., Nov 2014, In: Archives of Pharmacal Research. 37, 11, p. 1505 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

Inhibition of human Kv3.1 current expressed in Xenopus oocytes by the toxic venom fraction of Androctonus australis hector

Cheikh, A., Benkhalifa, R., Landoulsi, Z., Chatti, I. & Ayeb, M. E., Nov 2014, In: Archives of Pharmacal Research. 37, 11, p. 1445-1453 9 p.

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

2013

Subtype-selective activation of K_v7 channels by AaTXKβ_(2-64), a novel toxin variant from the Androctonus australis Scorpion venom

Landoulsi, Z., Miceli, F., Palmese, A., Amoresano, A., Marino, G., Ayeb, M. E., Taglialatela, M. & Benkhalifa, R., Nov 2013, In: Molecular Pharmacology. 84, 5, p. 763-773 11 p.

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Zied Landoulsi

Research output

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