Petra Marttila

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Petra Marttila

PhD, Ms.

 https://orcid.org/0000-0002-0115-8067

    • rue Nicolas-Ernest Barblé, 6

      1210 Luxembourg

      Luxembourg

    • 229
      Citations
    20162025

    Research activity per year

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    • 2025

      NAD kinase essentiality in cancer: in real life, it is all about folates

      Marttila, P. & Meiser, J., Jun 2025, In: Nature Metabolism. 7, 6, p. 1103-1105 3 p.

      Research output: Contribution to journal › Article › Research › peer-review

    • 2024

      Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

      Zhang, S. M. (Main author), Paulin, C. B. J., Shu, H., Yagüe-Capilla, M., Michel, M., Marttila, P., Ortis, F., Bwanika, H. C., Dirks, C., Venkatram, R. P., Wiita, E., Jemth, A.-S., Almlöf, I., Loseva, O., Hormann, F. M., Koolmeister, T., Linde, E., Lee, S., Llona-Miguez, S. & Haraldsson, M. & 7 others, Axelsson, H., Strömberg, K., Homan, E. J., Scobie, M., Lundbäck, T., Helleday, T. & Rudd, S. G., 16 Feb 2024, In: iScience. 27, 2, 108907.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      1 Citation (Scopus)

    • The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

      Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J., Wiita, E., Rasti, A., Warpman Berglund, U., Slipicevic, A., Mortusewicz, O. & Helleday, T., Sept 2024, In: Molecular Oncology. 18, 9, p. 2179-2195 17 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
    • 2022

      MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

      Karsten, S., Fiskesund, R., Zhang, X. M., Marttila, P., Sanjiv, K., Pham, T., Rasti, A., Bräutigam, L., Almlöf, I., Marcusson-Ståhl, M., Sandman, C., Platzack, B., Harris, R. A., Kalderén, C., Cederbrant, K., Helleday, T. & Warpman Berglund, U., Jan 2022, In: Cell Death and Differentiation. 29, 1, p. 246-261 16 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      8 Citations (Scopus)

    • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

      Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S., Green, A. C., Vallin, K. S. A., Sarno, A., Svensson, R., Göktürk, C., Pham, T., Jemth, A. S., Loseva, O., Cookson, V., Kiweler, N., Sandberg, L., Rasti, A. & Unterlass, J. E. & 48 others, Haraldsson, M., Andersson, Y., Scaletti, E. R., Bengtsson, C., Paulin, C. B. J., Sanjiv, K., Abdurakhmanov, E., Pudelko, L., Kunz, B., Desroses, M., Iliev, P., Färnegårdh, K., Krämer, A., Garg, N., Michel, M., Häggblad, S., Jarvius, M., Kalderén, C., Jensen, A. B., Almlöf, I., Karsten, S., Zhang, S. M., Häggblad, M., Eriksson, A., Liu, J., Glinghammar, B., Nekhotiaeva, N., Klingegård, F., Koolmeister, T., Martens, U., Llona-Minguez, S., Moulson, R., Nordström, H., Parrow, V., Dahllund, L., Sjöberg, B., Vargas, I. L., Vo, D. D., Wannberg, J., Knapp, S., Krokan, H. E., Arvidsson, P. I., Scobie, M., Meiser, J., Stenmark, P., Berglund, U. W., Homan, E. J. & Helleday, T., Feb 2022, In: Nature Cancer. 3, 2, p. 156-172 17 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      48 Citations (Scopus)

    • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

      Michel, M., Benítez-Buelga, C., Calvo, P. A., Hanna, B. M. F., Mortusewicz, O., Masuyer, G., Davies, J., Wallner, O., Sanjiv, K., Albers, J. J., Castañeda-Zegarra, S., Jemth, A. S., Visnes, T., Sastre-Perona, A., Danda, A. N., Homan, E. J., Marimuthu, K., Zhenjun, Z., Chi, C. N. & Sarno, A. & 37 others, Wiita, E., von Nicolai, C., Komor, A. J., Rajagopal, V., Müller, S., Hank, E. C., Varga, M., Scaletti, E. R., Pandey, M., Karsten, S., Haslene-Hox, H., Loevenich, S., Marttila, P., Rasti, A., Mamonov, K., Ortis, F., Schömberg, F., Loseva, O., Stewart, J., D'Arcy-Evans, N., Koolmeister, T., Henriksson, M., Michel, D., de Ory, A., Acero, L., Calvete, O., Scobie, M., Hertweck, C., Vilotijevic, I., Kalderén, C., Osorio, A., Perona, R., Stolz, A., Stenmark, P., Berglund, U. W., de Vega, M. & Helleday, T., 24 Jun 2022, In: Science. 376, 6600, p. 1471-1476 6 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      45 Citations (Scopus)
    • 2020

      Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

      Škerlová, J., Unterlass, J., Göttmann, M., Marttila, P., Homan, E., Helleday, T., Jemth, A. S. & Stenmark, P., 14 Aug 2020, In: Journal of Biological Chemistry. 295, 33, p. 11656-11668 13 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      16 Citations (Scopus)
    • 2018

      Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

      Gustafsson, N. M. S., Färnegårdh, K., Bonagas, N., Ninou, A. H., Groth, P., Wiita, E., Jönsson, M., Hallberg, K., Lehto, J., Pennisi, R., Martinsson, J., Norström, C., Hollers, J., Schultz, J., Andersson, M., Markova, N., Marttila, P., Kim, B., Norin, M. & Olin, T. & 1 others, Helleday, T., 1 Dec 2018, In: Nature Communications. 9, 1, 3872.

      Research output: Contribution to journal › Article › Research › peer-review

      96 Citations (Scopus)
    • 2016

      Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

      Cao, H., Wiemerslage, L., Marttila, P., Williams, M. J. & Schiöth, H. B., 24 Mar 2016, In: Basic and Clinical Pharmacology and Toxicology. 119, 3, p. 309-316 8 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      15 Citations (Scopus)
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