Petra Marttila

Petra Marttila

PhD, Ms.

    • rue Nicolas-Ernest Barblé, 6

      1210 Luxembourg

      Luxembourg

    • 156
      Citations
    20162024

    Research activity per year

    Search results

    • 2024

      Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

      Zhang, S. M., Paulin, C. B. J., Shu, H., Yagüe-Capilla, M., Michel, M., Marttila, P., Ortis, F., Bwanika, H. C., Dirks, C., Venkatram, R. P., Wiita, E., Jemth, A-S., Almlöf, I., Loseva, O., Hormann, F. M., Koolmeister, T., Linde, E., Lee, S., Llona-Miguez, S., Haraldsson, M., & 7 othersAxelsson, H., Strömberg, K., Homan, E. J., Scobie, M., Lundbäck, T., Helleday, T. & Rudd, S. G., 16 Feb 2024, In: iScience. 27, 2, 108907.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
    • The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

      Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J., Wiita, E., Rasti, A., Warpman Berglund, U., Slipicevic, A., Mortusewicz, O. & Helleday, T., 27 Mar 2024, (E-pub ahead of print) In: Molecular Oncology.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
    • 2023

      Targeting MTHFD1 and MTHFD2 as cancer treatment

      Marttila, P., 18 Sept 2023, Karolinska Institutet.

      Research output: Types of ThesisDoctoral Thesis

      Open Access
    • 2022

      MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

      Karsten, S., Fiskesund, R., Zhang, X. M., Marttila, P., Sanjiv, K., Pham, T., Rasti, A., Bräutigam, L., Almlöf, I., Marcusson-Ståhl, M., Sandman, C., Platzack, B., Harris, R. A., Kalderén, C., Cederbrant, K., Helleday, T. & Warpman Berglund, U., Jan 2022, In: Cell Death and Differentiation. 29, 1, p. 246-261 16 p.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      6 Citations (Scopus)
    • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

      Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S., Green, A. C., Vallin, K. S. A., Sarno, A., Svensson, R., Göktürk, C., Pham, T., Jemth, A. S., Loseva, O., Cookson, V., Kiweler, N., Sandberg, L., Rasti, A., Unterlass, J. E., & 48 othersHaraldsson, M., Andersson, Y., Scaletti, E. R., Bengtsson, C., Paulin, C. B. J., Sanjiv, K., Abdurakhmanov, E., Pudelko, L., Kunz, B., Desroses, M., Iliev, P., Färnegårdh, K., Krämer, A., Garg, N., Michel, M., Häggblad, S., Jarvius, M., Kalderén, C., Jensen, A. B., Almlöf, I., Karsten, S., Zhang, S. M., Häggblad, M., Eriksson, A., Liu, J., Glinghammar, B., Nekhotiaeva, N., Klingegård, F., Koolmeister, T., Martens, U., Llona-Minguez, S., Moulson, R., Nordström, H., Parrow, V., Dahllund, L., Sjöberg, B., Vargas, I. L., Vo, D. D., Wannberg, J., Knapp, S., Krokan, H. E., Arvidsson, P. I., Scobie, M., Meiser, J., Stenmark, P., Berglund, U. W., Homan, E. J. & Helleday, T., Feb 2022, In: Nature Cancer. 3, 2, p. 156-172 17 p.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      27 Citations (Scopus)
    • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

      Michel, M., Benítez-Buelga, C., Calvo, P. A., Hanna, B. M. F., Mortusewicz, O., Masuyer, G., Davies, J., Wallner, O., Sanjiv, K., Albers, J. J., Castañeda-Zegarra, S., Jemth, A. S., Visnes, T., Sastre-Perona, A., Danda, A. N., Homan, E. J., Marimuthu, K., Zhenjun, Z., Chi, C. N., Sarno, A., & 37 othersWiita, E., von Nicolai, C., Komor, A. J., Rajagopal, V., Müller, S., Hank, E. C., Varga, M., Scaletti, E. R., Pandey, M., Karsten, S., Haslene-Hox, H., Loevenich, S., Marttila, P., Rasti, A., Mamonov, K., Ortis, F., Schömberg, F., Loseva, O., Stewart, J., D'Arcy-Evans, N., Koolmeister, T., Henriksson, M., Michel, D., de Ory, A., Acero, L., Calvete, O., Scobie, M., Hertweck, C., Vilotijevic, I., Kalderén, C., Osorio, A., Perona, R., Stolz, A., Stenmark, P., Berglund, U. W., de Vega, M. & Helleday, T., 24 Jun 2022, In: Science. 376, 6600, p. 1471-1476 6 p.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      20 Citations (Scopus)
    • 2020

      Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

      Škerlová, J., Unterlass, J., Göttmann, M., Marttila, P., Homan, E., Helleday, T., Jemth, A. S. & Stenmark, P., 14 Aug 2020, In: Journal of Biological Chemistry. 295, 33, p. 11656-11668 13 p.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      13 Citations (Scopus)
    • 2018

      Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

      Gustafsson, N. M. S., Färnegårdh, K., Bonagas, N., Ninou, A. H., Groth, P., Wiita, E., Jönsson, M., Hallberg, K., Lehto, J., Pennisi, R., Martinsson, J., Norström, C., Hollers, J., Schultz, J., Andersson, M., Markova, N., Marttila, P., Kim, B., Norin, M., Olin, T., & 1 othersHelleday, T., 1 Dec 2018, In: Nature Communications. 9, 1, 3872.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      76 Citations (Scopus)
    • 2016

      Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

      Cao, H., Wiemerslage, L., Marttila, P., Williams, M. J. & Schiöth, H. B., 24 Mar 2016, In: Basic and Clinical Pharmacology and Toxicology. 119, 3, p. 309-316 8 p.

      Research output: Contribution to journalArticleResearchpeer-review

      Open Access
      14 Citations (Scopus)
    Your message has successfully been sent.
    Your message was not sent due to an error.