Petra Marttila

2025

NAD kinase essentiality in cancer: in real life, it is all about folates

Marttila, P. & Meiser, J., 2 May 2025, (E-pub ahead of print) In: Nature Metabolism. 3 p.

Research output: Contribution to journal › Article › Research › peer-review

2024

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

Zhang, S. M. (Main author), Paulin, C. B. J., Shu, H., Yagüe-Capilla, M., Michel, M., Marttila, P., Ortis, F., Bwanika, H. C., Dirks, C., Venkatram, R. P., Wiita, E., Jemth, A.-S., Almlöf, I., Loseva, O., Hormann, F. M., Koolmeister, T., Linde, E., Lee, S., Llona-Miguez, S. & Haraldsson, M. & 7 others, Axelsson, H., Strömberg, K., Homan, E. J., Scobie, M., Lundbäck, T., Helleday, T. & Rudd, S. G., 16 Feb 2024, In: iScience. 27, 2, 108907.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J., Wiita, E., Rasti, A., Warpman Berglund, U., Slipicevic, A., Mortusewicz, O. & Helleday, T., Sept 2024, In: Molecular Oncology. 18, 9, p. 2179-2195 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2023

Targeting MTHFD1 and MTHFD2 as cancer treatment

Marttila, P., 18 Sept 2023, Karolinska Institutet.

Research output: Types of Thesis › Doctoral Thesis

Open Access

2022

MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

Karsten, S., Fiskesund, R., Zhang, X. M., Marttila, P., Sanjiv, K., Pham, T., Rasti, A., Bräutigam, L., Almlöf, I., Marcusson-Ståhl, M., Sandman, C., Platzack, B., Harris, R. A., Kalderén, C., Cederbrant, K., Helleday, T. & Warpman Berglund, U., Jan 2022, In: Cell Death and Differentiation. 29, 1, p. 246-261 16 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

7 Citations (Scopus)

Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S., Green, A. C., Vallin, K. S. A., Sarno, A., Svensson, R., Göktürk, C., Pham, T., Jemth, A. S., Loseva, O., Cookson, V., Kiweler, N., Sandberg, L., Rasti, A. & Unterlass, J. E. & 48 others, Haraldsson, M., Andersson, Y., Scaletti, E. R., Bengtsson, C., Paulin, C. B. J., Sanjiv, K., Abdurakhmanov, E., Pudelko, L., Kunz, B., Desroses, M., Iliev, P., Färnegårdh, K., Krämer, A., Garg, N., Michel, M., Häggblad, S., Jarvius, M., Kalderén, C., Jensen, A. B., Almlöf, I., Karsten, S., Zhang, S. M., Häggblad, M., Eriksson, A., Liu, J., Glinghammar, B., Nekhotiaeva, N., Klingegård, F., Koolmeister, T., Martens, U., Llona-Minguez, S., Moulson, R., Nordström, H., Parrow, V., Dahllund, L., Sjöberg, B., Vargas, I. L., Vo, D. D., Wannberg, J., Knapp, S., Krokan, H. E., Arvidsson, P. I., Scobie, M., Meiser, J., Stenmark, P., Berglund, U. W., Homan, E. J. & Helleday, T., Feb 2022, In: Nature Cancer. 3, 2, p. 156-172 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

45 Citations (Scopus)

Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function

Michel, M., Benítez-Buelga, C., Calvo, P. A., Hanna, B. M. F., Mortusewicz, O., Masuyer, G., Davies, J., Wallner, O., Sanjiv, K., Albers, J. J., Castañeda-Zegarra, S., Jemth, A. S., Visnes, T., Sastre-Perona, A., Danda, A. N., Homan, E. J., Marimuthu, K., Zhenjun, Z., Chi, C. N. & Sarno, A. & 37 others, Wiita, E., von Nicolai, C., Komor, A. J., Rajagopal, V., Müller, S., Hank, E. C., Varga, M., Scaletti, E. R., Pandey, M., Karsten, S., Haslene-Hox, H., Loevenich, S., Marttila, P., Rasti, A., Mamonov, K., Ortis, F., Schömberg, F., Loseva, O., Stewart, J., D'Arcy-Evans, N., Koolmeister, T., Henriksson, M., Michel, D., de Ory, A., Acero, L., Calvete, O., Scobie, M., Hertweck, C., Vilotijevic, I., Kalderén, C., Osorio, A., Perona, R., Stolz, A., Stenmark, P., Berglund, U. W., de Vega, M. & Helleday, T., 24 Jun 2022, In: Science. 376, 6600, p. 1471-1476 6 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

44 Citations (Scopus)

2020

Crystal structures of human PAICS reveal substrate and product binding of an emerging cancer target

Škerlová, J., Unterlass, J., Göttmann, M., Marttila, P., Homan, E., Helleday, T., Jemth, A. S. & Stenmark, P., 14 Aug 2020, In: Journal of Biological Chemistry. 295, 33, p. 11656-11668 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

16 Citations (Scopus)

2018

Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination

Gustafsson, N. M. S., Färnegårdh, K., Bonagas, N., Ninou, A. H., Groth, P., Wiita, E., Jönsson, M., Hallberg, K., Lehto, J., Pennisi, R., Martinsson, J., Norström, C., Hollers, J., Schultz, J., Andersson, M., Markova, N., Marttila, P., Kim, B., Norin, M. & Olin, T. & 1 others, Helleday, T., 1 Dec 2018, In: Nature Communications. 9, 1, 3872.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

95 Citations (Scopus)

2016

Bis-(2-ethylhexyl) Phthalate Increases Insulin Expression and Lipid Levels in Drosophila melanogaster

Cao, H., Wiemerslage, L., Marttila, P., Williams, M. J. & Schiöth, H. B., 24 Mar 2016, In: Basic and Clinical Pharmacology and Toxicology. 119, 3, p. 309-316 8 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)

Petra Marttila

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