Projects per year
Personal profile
Education/Academic qualification
PhD, Main field of study: Medical science, Thesis title: "Targeting MTHFD1 and MTHFD2 as cancer treatment", Main supervisor: Prof. Thomas Helleday, Karolinska Institutet
Jan 2020 → Jan 2024
Award Date: 27 Oct 2023
Master, Main field of study: Biology, Uppsala University
Aug 2016 → Apr 2019
Award Date: 1 Apr 2019
Master, Main field of study: Chemistry, Uppsala University
Aug 2016 → Aug 2018
Award Date: 6 Aug 2018
Bachelor, Main field of study: Biology, Uppsala University
Aug 2013 → Jul 2016
Award Date: 1 Jul 2016
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Collaborations and top research areas from the last five years
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Projects
- 1 Not started
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CAMEL: The one-carbon metabolism as novel therapeutic target in leukemia/lymphoma
Paggetti, J. (PI), Meiser, J. (CoPI), Viry, E. (Partner), Marttila, P. (Partner) & Pierson, S. (Partner)
1/07/25 → 30/09/28
Project: Research
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NAD kinase essentiality in cancer: in real life, it is all about folates
Marttila, P. & Meiser, J., 2 May 2025, (E-pub ahead of print) In: Nature Metabolism. 3 p.Research output: Contribution to journal › Article › Research › peer-review
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Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
Zhang, S. M. (Main author), Paulin, C. B. J., Shu, H., Yagüe-Capilla, M., Michel, M., Marttila, P., Ortis, F., Bwanika, H. C., Dirks, C., Venkatram, R. P., Wiita, E., Jemth, A.-S., Almlöf, I., Loseva, O., Hormann, F. M., Koolmeister, T., Linde, E., Lee, S., Llona-Miguez, S. & Haraldsson, M. & 7 others, , 16 Feb 2024, In: iScience. 27, 2, 108907.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation
Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J., Wiita, E., Rasti, A., Warpman Berglund, U., Slipicevic, A., Mortusewicz, O. & Helleday, T., Sept 2024, In: Molecular Oncology. 18, 9, p. 2179-2195 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Targeting MTHFD1 and MTHFD2 as cancer treatment
Marttila, P., 18 Sept 2023, Karolinska Institutet.Research output: Types of Thesis › Doctoral Thesis
Open Access -
MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells
Karsten, S., Fiskesund, R., Zhang, X. M., Marttila, P., Sanjiv, K., Pham, T., Rasti, A., Bräutigam, L., Almlöf, I., Marcusson-Ståhl, M., Sandman, C., Platzack, B., Harris, R. A., Kalderén, C., Cederbrant, K., Helleday, T. & Warpman Berglund, U., Jan 2022, In: Cell Death and Differentiation. 29, 1, p. 246-261 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)