Petra Marttila

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Petra Marttila

PhD, Ms.

 https://orcid.org/0000-0002-0115-8067

    • rue Nicolas-Ernest Barblé, 6

      1210 Luxembourg

      Luxembourg

    • 191
      Citations
    20162024

    Research activity per year

    Personal profile

    Education/Academic qualification

    PhD, Main field of study: Medical science, Thesis title: "Targeting MTHFD1 and MTHFD2 as cancer treatment", Main supervisor: Prof. Thomas Helleday, Karolinska Institutet

    Jan 2020 → Jan 2024

    Award Date: 27 Oct 2023

    Master, Main field of study: Biology, Uppsala University

    Aug 2016 → Apr 2019

    Award Date: 1 Apr 2019

    Master, Main field of study: Chemistry, Uppsala University

    Aug 2016 → Aug 2018

    Award Date: 6 Aug 2018

    Bachelor, Main field of study: Biology, Uppsala University

    Aug 2013 → Jul 2016

    Award Date: 1 Jul 2016

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    Collaborations and top research areas from the last five years

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    • Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

      Zhang, S. M. (Main author), Paulin, C. B. J., Shu, H., Yagüe-Capilla, M., Michel, M., Marttila, P., Ortis, F., Bwanika, H. C., Dirks, C., Venkatram, R. P., Wiita, E., Jemth, A.-S., Almlöf, I., Loseva, O., Hormann, F. M., Koolmeister, T., Linde, E., Lee, S., Llona-Miguez, S. & Haraldsson, M. & 7 others, Axelsson, H., Strömberg, K., Homan, E. J., Scobie, M., Lundbäck, T., Helleday, T. & Rudd, S. G., 16 Feb 2024, In: iScience. 27, 2, 108907.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      1 Citation (Scopus)

    • The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation

      Marttila, P., Bonagas, N., Chalkiadaki, C., Stigsdotter, H., Schelzig, K., Shen, J., Farhat, C. M., Hondema, A., Albers, J., Wiita, E., Rasti, A., Warpman Berglund, U., Slipicevic, A., Mortusewicz, O. & Helleday, T., Sept 2024, In: Molecular Oncology. 18, 9, p. 2179-2195 17 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access

    • Targeting MTHFD1 and MTHFD2 as cancer treatment

      Marttila, P., 18 Sept 2023, Karolinska Institutet.

      Research output: Types of Thesis › Doctoral Thesis

      Open Access

    • MTH1 as a target to alleviate T cell driven diseases by selective suppression of activated T cells

      Karsten, S., Fiskesund, R., Zhang, X. M., Marttila, P., Sanjiv, K., Pham, T., Rasti, A., Bräutigam, L., Almlöf, I., Marcusson-Ståhl, M., Sandman, C., Platzack, B., Harris, R. A., Kalderén, C., Cederbrant, K., Helleday, T. & Warpman Berglund, U., Jan 2022, In: Cell Death and Differentiation. 29, 1, p. 246-261 16 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      6 Citations (Scopus)

    • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress

      Bonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S., Green, A. C., Vallin, K. S. A., Sarno, A., Svensson, R., Göktürk, C., Pham, T., Jemth, A. S., Loseva, O., Cookson, V., Kiweler, N., Sandberg, L., Rasti, A. & Unterlass, J. E. & 48 others, Haraldsson, M., Andersson, Y., Scaletti, E. R., Bengtsson, C., Paulin, C. B. J., Sanjiv, K., Abdurakhmanov, E., Pudelko, L., Kunz, B., Desroses, M., Iliev, P., Färnegårdh, K., Krämer, A., Garg, N., Michel, M., Häggblad, S., Jarvius, M., Kalderén, C., Jensen, A. B., Almlöf, I., Karsten, S., Zhang, S. M., Häggblad, M., Eriksson, A., Liu, J., Glinghammar, B., Nekhotiaeva, N., Klingegård, F., Koolmeister, T., Martens, U., Llona-Minguez, S., Moulson, R., Nordström, H., Parrow, V., Dahllund, L., Sjöberg, B., Vargas, I. L., Vo, D. D., Wannberg, J., Knapp, S., Krokan, H. E., Arvidsson, P. I., Scobie, M., Meiser, J., Stenmark, P., Berglund, U. W., Homan, E. J. & Helleday, T., Feb 2022, In: Nature Cancer. 3, 2, p. 156-172 17 p.

      Research output: Contribution to journal › Article › Research › peer-review

      Open Access
      36 Citations (Scopus)
    View all 9 research outputs