Projects per year
Dr Michel Vaillant started his career at the International medical research centre of Franceville, Gabon in 1995 working mainly on Malaria but also on HIV and immunology for 2 years. Then he worked in a small consulting epidemiology group in French Britain before joining in late 1997 a French constract research organization (CRO) for the pharmaceutical industry in Dijon, France. Since June 2003, he is with LIH. He is member of the Center for Methodology and Statistics (CCMS) within LIH from its creation, first as member of the group, then as deputy of Pr Stephen Senn and now as the Unit Head.
As member of a support unit to researchers, he has provided advices and operational help in various pathologies and fields (animal studies, epidemiology, clinical studies and trials). The unit provide support in study design and statistical methodology at the study concept level, protocol writing including power calculations. Michel has applied up-to-date statistical methods to different clinical and epidemiological studies from analysis of variance to linear mixed models or generalized mixed models. He has worked on several review and meta-analyses, individual patient data meta-analyses and secondary analyses. Currently his research topic is applied individual patient data network meta-analysis and generalized linear mixed models. He is interested in the methodology of clinical trials.
He has been working for several years in the field of neurodegenerative diseases such as Parkinson’s or Alzheimer diseases and other neurologic illnesses like Stroke or Migraine. He collaborated with physicians at the City Hospital of Luxembourg to analyse case series, case-control studies on sleep disturbance in PD as well as loss of emotion recognition but also an interventional study in Stroke. He is involved in the epidemiology and statistics platform within the National Centre for Excellence in Research on Parkinson’s Disease, a National Research Fund funded project lead by the University of Luxembourg.
He has developed collaborations with partners acting in Poverty Related Infectious Diseases. Dr Michel Vaillant has been project leader for the data management and statistics aspects of 3 large clinical trials (≈ 3400 patients) with WHO/TDR. He is also regularly member of the Data Safety Monitoring Committee of randomized clinical trials. He is currently involved in 4 consortia of accepted European grants (EDCTP) with 2 as Coordinator.
Dr Michel Vaillant is head of the CCMS within the newly formed Translational Medicine Operations Hub (TMOH), composed of 4 biostatisticians, 3 clinical data managers, one project manager and 2 fellows. The CCMS is providing support to LIH researchers for the design and analysis of their Public Health, Epidemiological and biological researches. The CCMS works closely with the CIEC and IBBL, also part of the TMOH, to offer all services required to design, run, analyse and report properly translational and clinical studies.
PhD, Isped School of Public Health, University of Bordeaux
1 Sept 2007 → 30 Sept 2010
Award Date: 17 Dec 2010
Master, epidemiology and public health, Isped School of Public Health, University of Bordeaux
1 Oct 1994 → 31 Aug 1995
Award Date: 30 Sept 1995
Biostatistician, International Clinical Trial Association
1 Sept 1998 → 30 May 2003
Biostatistician, Société d’EPIdémiologie et d’Analyse
1 Apr 1998 → 30 Jun 1998
Biostatistician, International Centre of Medical Research of Franceville
1 Apr 1996 → 31 Aug 1997
Biostatistician, Office National de la Chasse (Hunting National Office)
15 Sept 1995 → 31 Mar 1997
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MiniMox: A randomised parallel-group pharmacokinetic study to evaluate the bioequivalence of different formulations of moxidectin in adults
Vaillant, M., Sullivan, M., Batchelor, H. & Opoku, N. O.
1/01/21 → 30/07/25
5FC HIV-Crypto: Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease
Vaillant, M., Ribeiro, I., Loyse, A., Godfrey, S., Theron, H. B. & Kanyama, C.
1/04/20 → 31/12/24
MIMVac-Africa: A multilateral initiative to foster the clinical development of effective malaria vaccine candidates in Africa
Vaillant, M., Sirima, S. B., Agnandji, S. T., Aide, P., Olotu, A., Ndungu, F., Yazdanbakhsh, M., Viebig, N., Hill, A., Draper, S., Kremsner, P. G., Corradin, G., Horii, T. & Hoffman, S.
1/02/20 → 31/01/25
MoxiMultiDoseMod: Moxidectin for accelerating onchocerciasis elimination: A paediatric dose-finding study, a phase 3b trialc omparing efficacy and safety of annual and biannual moxidectin or ivermectin treatment and mathematical modelling of moxidectin and ivermectin based elimination strategies to support country policy decision
Vaillant, M., Sullivan, M., Ukety, T., Mandro, M., Stolk, W., Basáñez, M., Kuesel, A. C., Walker, M., Colebunders, R. & Opoku, N. O.
1/08/19 → 30/11/24
15/11/20 → 15/11/22
A Phase 2, Randomized, Multicenter, Placebo-Controlled, Proof-of-Concept Trial of Oral Fexinidazole in Adults with Chronic Indeterminate Chagas DiseaseTorrico, F., Gascón, J., Ortiz, L., Pinto, J., Rojas, G., Palacios, A., Barreira, F., Blum, B., Schijman, A. G., Vaillant, M., Strub-Wourgaft, N., Pinazo, M. J., Bilbe, G. & Ribeiro, I., 1 Feb 2023, In: Clinical Infectious Diseases. 76, 3, p. e1186-e1194
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access12 Citations (Scopus)
Association of diet quality indices with serum and metabolic biomarkers in participants of the ORISCAV-LUX-2 studyVahid, F., Hoge, A., Hébert, J. R., Bohn, T., Alkerwi, A., Noppe, S., Delagardelle, C., Beissel, J., Chioti, A., Stranges, S., Schmit, J. C., Lair, M. L., D’Incau, M., Pastore, J., Aguayo, G., Le Coroller, G., Vaillant, M., Samouda, H., Appenzeller, B., Malisoux, L., & 10 others, Aug 2023, In: European Journal of Nutrition. 62, 5, p. 2063-2085 23 p.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access2 Citations (Scopus)
Ngari, M. M., Rashid, M. A., Sanga, D., Mathenge, H., Agoro, O., Mberia, J. K., Katana, G. G., Vaillant, M. & Abdullahi, O. A., 30 May 2023, In: BMC Infectious Diseases. 23, 1, p. 362
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Correction: Machine learning for predicting neurodegenerative diseases in the general older population: a cohort studyAguayo, G. A., Zhang, L., Vaillant, M., Ngari, M., Perquin, M., Moran, V., Huiart, L., Krüger, R., Azuaje, F., Ferdynus, C. & Fagherazzi, G., 31 Jan 2023, In: BMC Medical Research Methodology. 23, 1, p. 32
Research output: Contribution to journal › Article › Research1 Citation (Scopus)
Low Diagnostic Performance of Thick Blood Smears of 50 $L in Comparison with Blood Direct Examination of 10 µL and Leukoconcentration Techniques among Loiasis-Suspected Patients with Low Microfilaremia in Gabon, Central Africa, using the STARD-BCLM GuidelinesM’Bondoukwé, N. P., Owono-Medang, M., Moussavou-Boussougou, M. N., Akoue, Y., Migueba, V., Bulaev, D., Neven, A., James, A. J. L., Ntsame-Ella, J., Mboumba, D. P. M., Atsame, J., Vaillant, M. & Bouyou-Akotet, M. K., 2023, (Research Square).
Research output: Working paper › PreprintOpen Access