Projects per year
Personal profile
Research interests
Dr Michel Vaillant tarted his career at the International medical research centre of Franceville, Gabon in 1995 working mainly on Malaria but also on HIV and immunology for 2 years. Then he worked in a small consulting epidemiology group in French Britain before joining in late 1997 a French constract research organization (CRO) for the pharmaceutical industry in Dijon, France. Since June 2003, he is with LIH. He is member of the Center for Methodology and Statistics (CCMS) within LIH from its creation, first as member of the group, then as deputy of Pr Stephen Senn and now as the Unit Head.
As member of a support unit to researchers, he has provided advices and operational help in various pathologies and fields (animal studies, epidemiology, clinical studies and trials). The unit provide support in study design and statistical methodology at the study concept level, protocol writing including power calculations. Michel has applied up-to-date statistical methods to different clinical and epidemiological studies from analysis of variance to linear mixed models or generalized mixed models. He has worked on several review and meta-analyses, individual patient data meta-analyses and secondary analyses. Currently his research topic is applied individual patient data network meta-analysis and generalized linear mixed models. He is interested in the methodology of clinical trials.
He has been working for several years in the field of neurodegenerative diseases such as Parkinson’s or Alzheimer diseases and other neurologic illnesses like Stroke or Migraine. He collaborated with physicians at the City Hospital of Luxembourg to analyse case series, case-control studies on sleep disturbance in PD as well as loss of emotion recognition but also an interventional study in Stroke. He is involved in the epidemiology and statistics platform within the National Centre for Excellence in Research on Parkinson’s Disease, a National Research Fund funded project lead by the University of Luxembourg.
He has developed collaborations with partners acting in Poverty Related Infectious Diseases. Dr Michel Vaillant has been project leader for the data management and statistics aspects of 3 large clinical trials (≈ 3400 patients) with WHO/TDR. He is also regularly member of the Data Safety Monitoring Committee of randomized clinical trials. He is currently involved in 4 consortia of accepted European grants (EDCTP) with 2 as Coordinator.
Dr Michel Vaillant is head of the CCMS within the newly formed Translational Medicine Operations Hub (TMOH), composed of 4 biostatisticians, 3 clinical data managers, one project manager and 2 fellows. The CCMS is providing support to LIH researchers for the design and analysis of their Public Health, Epidemiological and biological researches. The CCMS works closely with the CIEC and IBBL, also part of the TMOH, to offer all services required to design, run, analyse and report properly translational and clinical studies.
Education/Academic qualification
PhD, Isped School of Public Health, University of Bordeaux
1 Sep 2007 → 30 Sep 2010
Award Date: 17 Dec 2010
Master, Isped School of Public Health, University of Bordeaux
1 Oct 1994 → 31 Aug 1995
Award Date: 30 Sep 1995
External positions
Biostatistician, International Clinical Trial Association
1 Sep 1998 → 30 May 2003
Biostatistician, Société d’EPIdémiologie et d’Analyse
1 Apr 1998 → 30 Jun 1998
Biostatistician, International Centre of Medical Research of Franceville
1 Apr 1996 → 31 Aug 1997
Biostatistician, Office National de la Chasse (Hunting National Office)
15 Sep 1995 → 31 Mar 1997
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MiniMox: A randomised parallel-group pharmacokinetic study to evaluate the bioequivalence of different formulations of moxidectin in adults
Vaillant, M., Sullivan, M., Batchelor, H. & Opoku, N. O.
FNR - Fonds National de la Recherche, European and Developing Countries Clinical Trials Partnership (EDCTP)
1/01/21 → 30/07/25
Project: Research
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unCoVer: Unravelling Data for Rapid Evidence-Based Response to COVID-19
Huiart, L., Fagherazzi, G. & Vaillant, M.
15/11/20 → 15/11/22
Project: Research
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5FC HIV-Crypto: Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease
Vaillant, M., Ribeiro, I., Loyse, A., Godfrey, S., Theron, H. B. & Kanyama, C.
FNR - Fonds National de la Recherche
1/04/20 → 31/12/24
Project: Research
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MIMVac-Africa: A multilateral initiative to foster the clinical development of effective malaria vaccine candidates in Africa
Vaillant, M., Sirima, S. B., Agnandji, S. T., Aide, P., Olotu, A., Ndungu, F., Yazdanbakhsh, M., Viebig, N., Hill, A., Draper, S., Kremsner, P. G., Corradin, G., Horii, T. & Hoffman, S.
FNR - Fonds National de la Recherche
1/02/20 → 31/01/25
Project: Research
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MoxiMultiDoseMod: Moxidectin for accelerating onchocerciasis elimination: A paediatric dose-finding study, a phase 3b trialc omparing efficacy and safety of annual and biannual moxidectin or ivermectin treatment and mathematical modelling of moxidectin and ivermectin based elimination strategies to support country policy decision
Vaillant, M., Sullivan, M., Ukety, T., Mandro, M., Stolk, W., Basáñez, M., Kuesel, A. C., Walker, M., Colebunders, R. & Opoku, N. O.
FNR - Fonds National de la Recherche, European and Developing Countries Clinical Trials Partnership (EDCTP)
1/08/19 → 30/11/24
Project: Research
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Association between Dietary Factors and Constipation in Adults Living in Luxembourg and Taking Part in the ORISCAV-LUX 2 Survey
Rollet, M., Bohn, T., Vahid, F., ORISCAV Working Group, Pastore, J., Aguayo, G., Le Coroller, G., Vaillant, M., Samouda, H., Appenzeller, B., Malisoux, L., Couffignal, S., Gantenbein, M., Devaux, Y., Bejko, D., Fagherazzi, G., Perquin, M., Ruiz-Castell, M. & Ernens, I., 1 Jan 2022, In: Nutrients. 14, 1, 18 p., 122.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Combinatorial analysis reveals highly coordinated early-stage immune reactions that predict later antiviral immunity in mild COVID-19 patients
Capelle, C. M., Ciré, S., Domingues, O., Ernens, I., Hedin, F., Fischer, A., Snoeck, C. J., Ammerlaan, W., Konstantinou, M., Grzyb, K., Skupin, A., Carty, C. L., Hilger, C., Gilson, G., Celebic, A., Wilmes, P., Del Sol, A., Kaplan, I. M., Betsou, F., Abdelrahman, T. & 5 others, , 19 Apr 2022, In: Cell Reports Medicine. 3, 4, 100600.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Effect of a single dose of 8 mg moxidectin or 150 μg/kg ivermectin on O. volvulus skin microfilariae in a randomized trial: Differences between areas in the Democratic Republic of the Congo, Liberia and Ghana and impact of intensity of infection
Bakajika, D., Kanza, E. M., Opoku, N. O., Howard, H. M., Mambandu, G. L., Nyathirombo, A., Nigo, M. M., Kennedy, K. K., Masembe, S. L., Mumbere, M., Kataliko, K., Bolay, K. M., Attah, S. K., Olipoh, G., Asare, S., Vaillant, M., Halleux, C. M. & Kuesel, A. C., 27 Apr 2022, In: PLoS Neglected Tropical Diseases. 16, 4, p. e0010079Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Exploring the association between patient characteristics and emergency department use in Luxembourg
Moran, V., Foka, A. M., Aubart-Schuller, M., Leners, J-C., Stein, R., Vidaillac, C., Montanes, G., Vaillant, M., Menster, M., von der Wense, L. & Gantenbein, M., 2022, In: Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg. 2021, 2, p. 21-31 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile -
Prevalence and Cost of Care for Parkinson’s Disease in Luxembourg: An Analysis of National Healthcare Insurance Data
Schmitz, S., Vaillant, M., Renoux, C., Konsbruck, R. L., Hertz, P., Perquin, M., Pavelka, L., Krüger, R. & Huiart, L., May 2022, In: PharmacoEconomics - Open. 6, 3, p. 405-414 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access