Martyna Szpakowska

2024

Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1

Huber, M. E., Wurnig, S. L., Moumbock, A. F. A., Toy, L., Kostenis, E., Alonso Bartolomé, A., Szpakowska, M., Chevigné, A., Günther, S., Hansen, F. K. & Schiedel, M., 27 Jun 2024, (E-pub ahead of print) In: ChemMedChem. 10 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Fluorophore-Labeled Pyrrolones Targeting the Intracellular Allosteric Binding Site of the Chemokine Receptor CCR1

Toy, L., Huber, M. E., Lee, M., Bartolomé, A. A., Ortiz Zacarías, N. V., Nasser, S., Scholl, S., Zlotos, D. P., Mandour, Y. M., Heitman, L. H., Szpakowska, M., Chevigné, A. & Schiedel, M., 12 Jul 2024, In: ACS Pharmacology and Translational Science. 7, 7, p. 2080-2092 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

GRK specificity and Gβγ dependency determines the potential of a GPCR for arrestin-biased agonism

Matthees, E. S. F., Filor, J. C., Jaiswal, N., Reichel, M., Youssef, N., D’Uonnolo, G., Szpakowska, M., Drube, J., König, G. M., Kostenis, E., Chevigné, A., Godbole, A. & Hoffmann, C., 3 Jul 2024, In: Communications Biology. 7, 1, 802.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Heterogeneous expression of the atypical chemokine receptor ACKR3 in glioblastoma patient-derived tissue samples and cell cultures

Isci, D., Kuppens, A., Scalisi, J., Cokaiko, J., D'Uonnolo, G., Wantz, M., Szpakowska, M., Chevigné, A., Rogister, B. & Neirinckx, V., 20 Sept 2024, In: Scientific Reports. 14, 1, p. 21925 1 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism

Anbuhl, S. M., Dervillez, X., Neubacher, S., Schriek, A. I., Bobkov, V., de Taeye, S. W., Szpakowska, M., Siderius, M., Grossmann, T. N., Chevigné, A., Smit, M. J. & Heukers, R., Sept 2024, In: Biochemical Pharmacology. 227, 116457.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Novel Small-Molecule Atypical Chemokine Receptor 3 Agonists: Design, Synthesis, and Pharmacological Evaluation for Antiplatelet Therapy

Bayrak, A., Szpakowska, M., Dicenta-Baunach, V., Counson, M., Rasch, A., Rohlfing, A. K., Chevigné, A., Gawaz, M., Laufer, S. A. & Pillaiyar, T., 22 Aug 2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14553-14573 21 p.

Research output: Contribution to journal › Article › Research › peer-review

Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma

D'Uonnolo, G., Isci, D., Nosirov, B., Kuppens, A., Wantz, M., Nazarov, P. V., Golebiewska, A., Rogister, B., Chevigné, A., Neirinckx, V. (Main author) & Szpakowska, M., 30 Sept 2024, In: Computers in Biology and Medicine. 182, 109197.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

Pharmacological Characterization and Radiolabeling of VUF15485, a High-Affinity Small-Molecule Agonist for the Atypical Chemokine Receptor ACKR3

Zarca, A. M., Adlere, I., Viciano, C. P., Arimont-Segura, M., Meyrath, M., Simon, I. A., Bebelman, J. P., Laan, D., Custers, H. G. J., Janssen, E., Versteegh, K. L., Buzink, M. C. M. L., Nesheva, D. N., Bosma, R., de Esch, I. J. P., Vischer, H. F., Wijtmans, M., Szpakowska, M., Chevigné, A. & Hoffmann, C. & 5 others, de Graaf, C., Zarzycka, B. A., Windhorst, A. D., Smit, M. J. & Leurs, R., 14 Mar 2024, In: Molecular Pharmacology. 105, 4, p. 301-312 12 p.

Research output: Contribution to journal › Article › Research › peer-review

4 Citations (Scopus)

Systematic assessment of chemokine ligand bias at the human chemokine receptor CXCR2 indicates G protein bias over β-arrestin recruitment and receptor internalization

Boon, K., Vanalken, N., Szpakowska, M., Chevigné, A., Schols, D. & Van Loy, T., 17 Jan 2024, In: Cell Communication and Signaling. 22, 1, 12 p., 43.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

1 Citation (Scopus)

Systematic Assessment of Human CCR7 Signalling Using NanoBRET Biosensors Points towards the Importance of the Cellular Context

Vanalken, N., Boon, K., Szpakowska, M., Chevigné, A., Schols, D. & Van Loy, T., 14 Mar 2024, In: Biosensors. 14, 3, 142.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2023

Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors

Gray, A. L., Karlsson, R., Roberts, A. R. E., Ridley, A. J. L., Pun, N., Khan, B., Lawless, C., Luís, R., Szpakowska, M., Chevigné, A., Hughes, C. E., Medina-Ruiz, L., Birchenough, H. L., Mulholland, I. Z., Salanga, C. L., Yates, E. A., Turnbull, J. E., Handel, T. M., Graham, G. J. & Jowitt, T. A. & 4 others, Schiessl, I., Richter, R. P., Miller, R. L. & Dyer, D. P., 31 Jan 2023, In: Cell Reports. 42, 1, 111930.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

21 Citations (Scopus)

Formate promotes invasion and metastasis in reliance on lipid metabolism

Delbrouck, C., Kiweler, N., Chen, O., Pozdeev, V. I., Haase, L., Neises, L., Oudin, A., Fouquier d'Hérouël, A., Shen, R., Schlicker, L., Halder, R., Lesur, A., Schuster, A., Lorenz, N. I., Jaeger, C., Feucherolles, M., Frache, G., Szpakowska, M., Chevigne, A. & Ronellenfitsch, M. W. & 7 others, Moussay, E., Piraud, M., Skupin, A., Schulze, A., Niclou, S. P., Letellier, E. & Meiser, J., 26 Sept 2023, In: Cell Reports. 42, 9, 113034.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

5 Citations (Scopus)

GPR182 is a broadly scavenging atypical chemokine receptor influencing T-independent immunity

Melgrati, S., Gerken, O. J., Artinger, M., Radice, E., Szpakowska, M., Chevigné, A., D’Uonnolo, G., Antonello, P., Thelen, S., Pelczar, P., Legler, D. F. & Thelen, M., 24 Jul 2023, In: Frontiers in Immunology. 14, 1242531.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

3 Citations (Scopus)

Inhibition of MYC translation through targeting of the newly identified PHB-eIF4F complex as a therapeutic strategy in CLL

Largeot, A., Klapp, V., Viry, E., Gonder, S., Fernandez Botana, I., Blomme, A., Benzarti, M., Pierson, S., Duculty, C., Marttila, P., Wierz, M., Gargiulo, E., Pagano, G., An, N., El Hachem, N., Perez Hernandez, D., Chakraborty, S., Ysebaert, L., François, J. H. & Cortez Clemente, S. & 13 others, Berchem, G., Efremov, D. G., Dittmar, G., Szpakowska, M., Chevigné, A., Nazarov, P. V., Helleday, T., Close, P., Meiser, J., Stamatopoulos, B., Désaubry, L., Paggetti, J. (Main author) & Moussay, E. (Main author), 29 Jun 2023, In: Blood. 141, 26, p. 3166-3183 18 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

9 Citations (Scopus)

Inhibition of MYC translation through targeting of the newly identified PHB-EIF4F complex as therapeutic strategy inchronic lymphocytic leukemia (CLL)

Largeot, A., Klapp, V., Viry, E., Gonder, S., Botana, I. F., Blomme, A., Benzarti, M., Pierson, S., Duculty, C., Marttila, P., Wierz, M., Gargiulo, E., Pagano, G., An, N., El Hachem, N., Perez Hernandez, D., Chakraborty, S., Ysebaert, L., François, J.-H. & Cortez, S. & 13 others, Berchem, G., Efremov, D. G., Dittmar, G., Szpakowska, M., Chevigne, A., Nazarov, P. V., Helleday, T., Close, P., Meiser, J., Stamatopoulos, B., Désaubry, L., Paggetti, J. & Moussay, E., Aug 2023, In: HemaSphere. 7, S3, S141.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

Nanoluciferase-based complementation assays to monitor activation, modulation and signaling of receptor tyrosine kinases (RTKs)

Dosquet, H., Neirinckx, V., Meyrath, M., Wantz, M., Haan, S., Niclou, S. P. (Main author), Szpakowska, M. (Main author) & Chevigné, A., 20 Mar 2023, In: Methods in Enzymology. 682, p. 1-16 16 p.

Research output: Contribution to journal › Article › Research › peer-review

New pairings and deorphanization among the atypical chemokine receptor family — physiological and clinical relevance

Szpakowska, M., D’Uonnolo, G., Luís, R., Alonso Bartolomé, A., Thelen, M., Legler, D. F. & Chevigné, A., 20 Apr 2023, In: Frontiers in Immunology. 14, 1133394.

Research output: Contribution to journal › Short survey › peer-review

Open Access

6 Citations (Scopus)

Reduced G protein signaling despite impaired internalization and β-arrestin recruitment in patients carrying a CXCR4Leu317fsX3 mutation causing WHIM syndrome

Kumar, R., Milanesi, S., Szpakowska, M., Dotta, L., Di Silvestre, D., Trotta, A. M., Bello, A. M., Giacomelli, M., Benedito, M., Azevedo, J., Pereira, A., Cortesao, E., Vacchini, A., Castagna, A., Pinelli, M., Moratto, D., Bonecchi, R., Locati, M., Scala, S. & Chevigné, A. & 2 others, Borroni, E. M. & Badolato, R., 8 Mar 2023, In: JCI insight. 8, 5, e145688.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

5 Citations (Scopus)

Reply to: How carvedilol does not activate β₂-adrenoceptors

Kostenis, E., Gomeza, J., Miess-Tanneberg, E., Blum, N. K., Benkel, T., Chevigné, A., Hoffmann, C., Kolb, P., Nikolaev, V., Waldhoer, M., Szpakowska, M., Inoue, A. & Schulz, S., 30 Nov 2023, In: Nature Communications. 14, 1, 7867.

Research output: Contribution to journal › Letter › peer-review

Open Access

2022

Atypical opioid receptors: unconventional biology and therapeutic opportunities

Palmer, C. B., Meyrath, M., Canals, M., Kostenis, E., Chevigné, A. (Main author) & Szpakowska, M., May 2022, In: Pharmacology and Therapeutics. 233, 108014.

Research output: Contribution to journal › Review article › peer-review

Open Access

19 Citations (Scopus)

Computationally designed GPCR quaternary structures bias signaling pathway activation

Paradis, J. S., Feng, X., Murat, B., Jefferson, R. E., Sokrat, B., Szpakowska, M., Hogue, M., Bergkamp, N. D., Heydenreich, F. M., Smit, M. J., Chevigné, A., Bouvier, M. & Barth, P., 11 Nov 2022, In: Nature Communications. 13, 1, 6826.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

11 Citations (Scopus)

Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor

Kleist, A. B., Jenjak, S., Sente, A., Laskowski, L. J., Szpakowska, M., Calkins, M. M., Anderson, E. I., McNally, L. M., Heukers, R., Bobkov, V., Peterson, F. C., Thomas, M. A., Chevigné, A., Smit, M. J., McCorvy, J. D., Babu, M. M. & Volkman, B. F., 8 Jul 2022, In: Science. 377, 6602, p. 222-228 7 p.

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

Conolidine analogues as selective ACKR3 modulators for the treatment of cancer and cardiovascular diseases

Chevigne, A. (Inventor), Szpakowska, M. (Inventor), Namjoshi, O. A. (Inventor), Blough, B. E. (Inventor), Decker, A. M. (Inventor) & Meyrath, M. (Inventor), 30 Jun 2022, IPC No. A61K31/397; A61K31/4025; A61K31/404; A61K31/407; A61K31/439; A61K31/4439; A61K31/454; A61K31/496; A61K31/499; A61K31/551; A61P13/12; A61P17/02; A61P25/28; A61P29/00; A61P3/04; A61P31/12; A61P31/18; A61P35/00; A61P37/08; A61P9/00; A61P9/10; C07D401/06; C07D403/06; C07D403/12; C07D471/18; C07D487/04;, Patent No. WO2022136486A1, 22 Dec 2021, Priority date 22 Dec 2020, Priority No. EP20216606A

Research output: Patent

Discovery and Development of First-in-Class ACKR3/CXCR7 Superagonists for Platelet Degranulation Modulation

Bayrak, A., Mohr, F., Kolb, K., Szpakowska, M., Shevchenko, E., Dicenta, V., Rohlfing, A. K., Kudolo, M., Pantsar, T., Günther, M., Kaczor, A. A., Poso, A., Chevigné, A., Pillaiyar, T., Gawaz, M. & Laufer, S. A., 13 Oct 2022, In: Journal of Medicinal Chemistry. 65, 19, p. 13365-13384 20 p.

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Discovery of small-molecules targeting the CCL20/CCR6 axis as first-in-class inhibitors for inflammatory bowel diseases

Martina, M. G., Giorgio, C., Allodi, M., Palese, S., Barocelli, E., Ballabeni, V., Szpakowska, M., Chevigné, A., Piet van Hamburg, J., Davelaar, N., Lubberts, E., Bertoni, S. & Radi, M., 5 Dec 2022, In: European Journal of Medicinal Chemistry. 243, 114703.

Research output: Contribution to journal › Article › Research › peer-review

13 Citations (Scopus)

Editorial: Emerging receptors as new targets in health and disease

Dam, J., Hanson, J. & Szpakowska, M., 16 Nov 2022, In: Frontiers in Endocrinology. 13, 1073794.

Research output: Contribution to journal › Editorial

Open Access

Erratum: Activation of the Orphan G Protein-Coupled Receptor GPR27 by Surrogate Ligands Promotes b-Arrestin 2 Recruitment (Mol Pharmacol (2017) 91 (595-608) DOI: 10.1124/mol.116.107714)

Dupuis, N., Laschet, C., Franssen, D., Szpakowska, M., Gilissen, J., Geubelle, P., Soni, A., Parent, A. S., Pirotte, B., Chevigné, A., Twizere, J. C. & Hanson, J., 1 Apr 2022, In: Molecular Pharmacology. 101, 4, p. 274 1 p.

Research output: Contribution to journal › Comment/debate

Open Access

How Carvedilol activates β2-adrenoceptors

Benkel, T., Zimmermann, M., Zeiner, J., Bravo, S., Merten, N., Lim, V. J. Y., Matthees, E. S. F., Drube, J., Miess-Tanneberg, E., Malan, D., Szpakowska, M., Monteleone, S., Grimes, J., Koszegi, Z., Lanoiselée, Y., O’Brien, S., Pavlaki, N., Dobberstein, N., Inoue, A. & Nikolaev, V. & 10 others, Calebiro, D., Chevigné, A., Sasse, P., Schulz, S., Hoffmann, C., Kolb, P., Waldhoer, M., Simon, K., Gomeza, J. & Kostenis, E., 19 Nov 2022, In: Nature Communications. 13, 1, 7109.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

23 Citations (Scopus)

Nanoluciferase-based cell fusion assay for rapid and high-throughput assessment of SARS-CoV-2-neutralizing antibodies in patient samples

Meyrath, M., Szpakowska, M., Plesseria, J. M., Domingues, O., Langlet, J., Weber, B., Krüger, R., Ollert, M. (Main author) & Chevigné, A., 8 Oct 2022, In: Methods in Enzymology. 675, p. 351-381 31 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Nanoluciferase-based complementation assay for systematic profiling of GPCR–GRK interactions

Palmer, C. B., D'Uonnolo, G. (Main author), Luís, R. (Main author), Meyrath, M., Uchański, T., Chevigné, A. (Main author) & Szpakowska, M., Jun 2022, In: Methods in Cell Biology. 169, p. 309-321 13 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

Nanoluciferase-based methods to monitor activation, modulation and trafficking of atypical chemokine receptors

Luís, R., D'Uonnolo, G., Palmer, C. B., Meyrath, M., Uchański, T., Wantz, M., Rogister, B., Janji, B., Chevigné, A. & Szpakowska, M., 2022, In: Methods in Cell Biology. 169, p. 279-294 16 p.

Research output: Contribution to journal › Article › Research › peer-review

9 Citations (Scopus)

Patient-oriented perspective on chemokine receptor expression and function in glioma

Isci, D., D’uonnolo, G. (Main author), Wantz, M., Rogister, B., Lombard, A., Chevigné, A., Szpakowska, M. & Neirinckx, V., 1 Jan 2022, In: Cancers. 14, 1, 130.

Research output: Contribution to journal › Review article › peer-review

Open Access

6 Citations (Scopus)

Targeting translation by disrupting the newly identified prohibitin-eif4f complex as a novel therapeutic strategy in chronic lymphocytic leukemia

Largeot, A., Klapp, V., Gonder, S., Viry, E., Szpakowska, M., Hernandez, D. P., Dittmar, G., Chevigné, A., Ysebaert, L. & Stamatopoulos, B., Jun 2022, In: HemaSphere. 6, Suppl.3, p. 518-519 2 p., P619.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

The Extended N-Terminal Domain Confers Atypical Chemokine Receptor Properties to CXCR3-B

D'Uonnolo, G., Reynders, N. (Main author), Meyrath, M., Abboud, D., Uchanski, T., Laeremans, T., Volkman, B. F., Janji, B., Hanson, J., Szpakowska, M. (Main author) & Chevigne, A., 1 Jun 2022, In: Frontiers in Immunology. 13, 868579.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

7 Citations (Scopus)

2021

Computationally designed GPCR quaternary structures bias signaling pathway activation

Paradis, J. S., Feng, B., Murat, B., Jefferson, R., Szpakowska, M., Hogue, M., Bergkamp, N. D., Heydenreich, F. M., Smit, M. J., Chevigne, A., Bouvier, M. & Barth, P., 23 Sept 2021, (bioRxiv).

Research output: Working paper › Preprint

Cxcl10 is an agonist of the cc family chemokine scavenger receptor ackr2/d6

Chevigné, A., Janji, B., Meyrath, M., Reynders, N., D’uonnolo, G., Uchański, T., Xiao, M., Berchem, G., Ollert, M., Kwon, Y. J., Noman, M. Z. & Szpakowska, M., 2 Mar 2021, In: Cancers. 13, 5, p. 1-13 13 p., 1054.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

26 Citations (Scopus)

CXCR4-Binding Positron Emission Tomography Tracers Link Monocyte Recruitment and Endothelial Injury in Murine Atherosclerosis

Baba, O., Huang, L. H., Elvington, A., Szpakowska, M., Sultan, D., Heo, G. S., Zhang, X., Luehmann, H., Detering, L., Chevigne, A., Liu, Y. & Randolph, G. J., Feb 2021, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 41, 2, p. 822-836 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

16 Citations (Scopus)

Illuminating the signaling enigma of Carvedilol

Benkel, T., Zimmermann, M., Monteleone, S., Lim, V., Pavlaki, N., Malan, D., Matthees, E., Szpakowska, M., Miess, E., Zeiner, J., Haeberlein, F., Simon, K., Gomeza, J., Inoue, A., Schulz, S., Chevigne, A., Hoffmann, C., Sasse, P., Nikolaev, V. & Kolb, P. & 2 others, Waldhoer, M. & Kostenis, E., Mar 2021, In: Naunyn-Schmiedeberg's Archives of Pharmacology. 394, Suppl.1, p. S22-S22 74.

Research output: Contribution to journal › Meeting Abstract › peer-review

Open Access

Maraviroc prevents hcc development by suppressing macrophages and the liver progenitor cell response in a murine chronic liver disease model

Passman, A. M., Strauss, R. P., McSpadden, S. B., Finch-Edmondson, M., Andrewartha, N., Woo, K. H., Diepeveen, L. A., Zhao, W., Fernández-Irigoyen, J., Santamaría, E., Medina-Ruiz, L., Szpakowska, M., Chevigné, A., Park, H., Carlessi, R., Tirnitz-Parker, J. E. E., Blanco, J. R., London, R., Callus, B. A. & Elsegood, C. L. & 4 others, Baker, M. V., Martínez, A., Yeoh, G. C. T. & Ochoa-Callejero, L., Oct 2021, In: Cancers. 13, 19, 4935.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

10 Citations (Scopus)

Proadrenomedullin N-Terminal 20 Peptides (PAMPs) Are Agonists of the Chemokine Scavenger Receptor ACKR3/CXCR7

Meyrath, M., Palmer, C. B., Reynders, N., Vanderplasschen, A., Ollert, M., Bouvier, M., Szpakowska, M. (Main author) & Chevigné, A., 9 Apr 2021, In: ACS Pharmacology and Translational Science. 4, 2, p. 813-823 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)

Specific ACKR2 modulators for use in therapy

Janji, B. (Inventor), Noman, M. Z. (Inventor), Chevigne, A. (Inventor), Szpakowska, M. (Inventor), Berchem, G. (Inventor) & Ollert, M. (Inventor), 21 Jan 2021, IPC No. A61K39/395; A61K48/00; A61P35/00; C07K16/28; C12N15/113, Patent No. WO 2021/009251, 15 Jul 2020, Priority date 15 Jul 2019, Priority No. EP19186373A

Research output: Patent

Open Access

Systematic reassessment of chemokine-receptor pairings confirms CCL20 but not CXCL13 and extends the spectrum of ACKR4 agonists to CCL22

Meyrath, M., Reynders, N., Uchański, T., Chevigné, A. (Main author) & Szpakowska, M., Feb 2021, In: Journal of Leukocyte Biology. 109, 2, p. 373-376 4 p.

Research output: Contribution to journal › Article › Research › peer-review

16 Citations (Scopus)

The natural analgesic conolidine targets the newly identified opioid scavenger ACKR3/CXCR7

Szpakowska, M., Decker, A. M., Meyrath, M., Palmer, C. B., Blough, B. E., Namjoshi, O. A. & Chevigné, A., 2 Jun 2021, In: Signal Transduction and Targeted Therapy. 6, 1, p. 209 209.

Research output: Contribution to journal › Letter › peer-review

Open Access

16 Citations (Scopus)

2020

Assessment of Biased Agonism among Distinct Synthetic Cannabinoid Receptor Agonist Scaffolds

Wouters, E., Walraed, J., Robertson, M. J., Meyrath, M., Szpakowska, M., Chevigné, A., Skiniotis, G. & Stove, C., 10 Apr 2020, In: ACS Pharmacology and Translational Science. 3, 2, p. 285-295 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

43 Citations (Scopus)

CXCL14 Preferentially Synergizes With Homeostatic Chemokine Receptor Systems

Kouzeli, A., Collins, P. J., Metzemaekers, M., Meyrath, M., Szpakowska, M., Artinger, M., Struyf, S., Proost, P., Chevigne, A., Legler, D. F., Eberl, M. & Moser, B., 5 Oct 2020, In: Frontiers in Immunology. 11, 561404.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

21 Citations (Scopus)

Fusion proteins comprising a cytokine and scaffold protein

Steyaert, J. (Inventor), Pardon, E. (Inventor), Wohlkönig, A. (Inventor), Kalichuk, V. (Inventor), Vranken, W. (Inventor), Uchanski, T. (Inventor), Chevigné, A. (Inventor) & Szpakowska, M. (Inventor), 25 Jun 2020, IPC No. C07K14/205; C07K14/52; C07K14/715; C07K19/00, Patent No. WO2020127983A1, Priority date 21 Dec 2018, Priority No. EP18215463A

Research output: Patent

Novel selective ACKR3 modulators and uses thereof

Chevigne, A. (Inventor), Meyrath, M. (Inventor) & Szpakowska, M. (Inventor), 12 Nov 2020, IPC No. A61K38/00; A61K47/62; A61K47/64; A61K48/00; C07K7/08; C12N15/86; G01N33/58, Patent No. WO 2020/225070A1, 30 Apr 2020, Priority date 3 May 2019, Priority No. EP19172560A

Research output: Patent

Open Access

Structural Features of an Extended C-Terminal Tail Modulate the Function of the Chemokine CCL21

Moussouras, N. A., Hjortø, G. M., Peterson, F. C., Szpakowska, M., Chevigné, A., Rosenkilde, M. M., Volkman, B. F. & Dwinell, M. B., 7 Apr 2020, In: Biochemistry. 59, 13, p. 1338-1350 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

11 Citations (Scopus)

The atypical chemokine receptor ACKR3/CXCR7 is a broad-spectrum scavenger for opioid peptides

Meyrath, M., Szpakowska, M. (Main author), Zeiner, J., Massotte, L., Merz, M. P., Benkel, T., Simon, K., Ohnmacht, J., Turner, J. D., Krüger, R., Seutin, V., Ollert, M., Kostenis, E. & Chevigné, A., 1 Dec 2020, In: Nature Communications. 11, 1, 3033.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

73 Citations (Scopus)

The diverse and complex roles of atypical chemokine receptors in cancer: From molecular biology to clinical relevance and therapy

Sjöberg, E., Meyrath, M., Chevigné, A., Östman, A., Augsten, M. & Szpakowska, M., 2020, GPCR Signaling in Cancer. Academic Press Inc., p. 99-138 40 p. (Advances in Cancer Research; vol. 145).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

24 Citations (Scopus)

Martyna Szpakowska

Research output

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