Research output

Research output per year 2001 2009 2015 2018 2020 2021

• 20 Article
• 1 Chapter
• 1 Review article
• 1 Doctoral Thesis

Research output per year

Research output per year

Search results

• 2021

  Deep sequencing of sncRNAs reveals hallmarks and regulatory modules of the transcriptome during Parkinson’s disease progression

  Kern, F., Fehlmann, T., Violich, I., Alsop, E., Hutchins, E., Kahraman, M., Grammes, N. L., Guimarães, P., Backes, C., Poston, K. L., Casey, B., Balling, R., Geffers, L., Krüger, R., Galasko, D., Mollenhauer, B., Meese, E., Wyss-Coray, T., Craig, D. W., Van Keuren-Jensen, K., & 1 othersKeller, A., 15 Mar 2021, In: Nature Aging. 1, 3, p. 309-322 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Small Untranslated RNA 100%
  • High-Throughput Nucleotide Sequencing 79%
  • Transcriptome 75%
  • Parkinson Disease 69%
  • Disease Progression 65%
  14 Citations (Scopus)
• 2020

  Common diseases alter the physiological age-related blood microRNA profile

  Fehlmann, T., Lehallier, B., Schaum, N., Hahn, O., Kahraman, M., Li, Y., Grammes, N., Geffers, L., Backes, C., Balling, R., Kern, F., Krüger, R., Lammert, F., Ludwig, N., Meder, B., Fromm, B., Maetzler, W., Berg, D., Brockmann, K., Deuschle, C., & 8 othersvon Thaler, A. K., Eschweiler, G. W., Milman, S., Barziliai, N., Reichert, M., Wyss-Coray, T., Meese, E. & Keller, A., Dec 2020, In: Nature Communications. 11, 1, 5958.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  • MicroRNA 100%
  • blood 77%
  • MicroRNAs 68%
  • profiles 43%
  • biomarkers 30%
  28 Citations (Scopus)

• Evaluating the Use of Circulating MicroRNA Profiles for Lung Cancer Detection in Symptomatic Patients

  Fehlmann, T., Kahraman, M., Ludwig, N., Backes, C., Galata, V., Keller, V., Geffers, L., Mercaldo, N., Hornung, D., Weis, T., Kayvanpour, E., Abu-Halima, M., Deuschle, C., Schulte, C., Suenkel, U., Von Thaler, A. K., Maetzler, W., Herr, C., Fähndrich, S., Vogelmeier, C., & 21 othersGuimaraes, P., Hecksteden, A., Meyer, T., Metzger, F., Diener, C., Deutscher, S., Abdul-Khaliq, H., Stehle, I., Haeusler, S., Meiser, A., Groesdonk, H. V., Volk, T., Lenhof, H. P., Katus, H., Balling, R., Meder, B., Kruger, R., Huwer, H., Bals, R., Meese, E. & Keller, A., May 2020, In: JAMA Oncology. 6, 5, p. 714-723 10 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Circulating MicroRNA 100%
  • Lung Neoplasms 56%
  • MicroRNAs 38%
  • Cohort Studies 10%
  • Lung Diseases 9%
  57 Citations (Scopus)

• Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

  Baldini, F., Hertel, J., Sandt, E., Thinnes, C. C., Neuberger-Castillo, L., Pavelka, L., Betsou, F., Krüger, R., Thiele, I., Allen, D., Ammerlann, W., Aurich, M., Balling, R., Banda, P., Beaumont, K., Becker, R., Berg, D., Binck, S., Bisdorff, A., Bobbili, D., & 93 othersBrockmann, K., Calmes, J., Diederich, N., Dondelinger, R., Esteves, D., Ferrand, J. Y., Fleming, R., Gantenbein, M., Gasser, T., Gawron, P., Geffers, L., Giarmana, V., Glaab, E., Gomes, C. P. C., Goncharenko, N., Graas, J., Graziano, M., Groues, V., Grünewald, A., Gu, W., Hammot, G., Hanff, A. M., Hansen, L., Hansen, M., Haraldsdöttir, H., Heirendt, L., Herbrink, S., Herzinger, S., Heymann, M., Hiller, K., Hipp, G., Hu, M., Huiart, L., Hundt, A., Jacoby, N., Jarosław, J., Jaroz, Y., Kolber, P., Kutzera, J., Landoulsi, Z., Larue, C., Lentz, R., Lie-Pelt, I., Liszka, R., Longhino, L., Lorentz, V., Mackay, C., Maetzler, W., Marcus, K., Marques, G., Martens, J., Mathay, C., Matyjaszczyk, P., May, P., Meisch, F., Menster, M., Minelli, M., Mittelbronn, M., Mollenhauer, B., Mommaerts, K., Moreno, C., Mühlschlegel, F., Nati, R., Nehrbass, U., Nickels, S., Nicolai, B., Nicolay, J. P., Noronha, A., Oertel, W., Ostaszewski, M., Pachchek, S., Pauly, C., Perquin, M., Reiter, D., Rosety, I., Rump, K., Satagopam, V., Schlesser, M., Schmitz, S., Schmitz, S., Schneider, R., Schwamborn, J., Schweicher, A., Simons, J., Stute, L., Trefois, C., Trezzi, J. P., Vaillant, M., Vasco, D., Vyas, M., Wade-Martins, R., Wilmes, P. & Aguayo, G., 9 Jun 2020, In: BMC Biology. 18, 1, 62.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  • Parkinson disease 100%
  • Gastrointestinal Microbiome 72%
  • microbiome 71%
  • Parkinson Disease 61%
  • digestive system 59%
  80 Citations (Scopus)
• 2019

  Large-scale validation of miRNAs by disease association, evolutionary conservation and pathway activity

  Fehlmann, T., Laufer, T., Backes, C., Kahramann, M., Alles, J., Fischer, U., Minet, M., Ludwig, N., Kern, F., Kehl, T., Galata, V., Düsterloh, A., Schrörs, H., Kohlhaas, J., Bals, R., Huwer, H., Geffers, L., Krüger, R., Balling, R., Lenhof, H. P., & 2 othersMeese, E. & Keller, A., 2 Jan 2019, In: RNA Biology. 16, 1, p. 93-103 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • MicroRNAs 100%
  • High-Throughput Nucleotide Sequencing 37%
  • Genes 5%
  4 Citations (Scopus)
• 2018

  Meningioma transcription factors link cell lineage with systemic metabolic cues

  Du, Z., Brewster, R., Merrill, P. H., Chmielecki, J., Francis, J., Aizer, A., Abedalthagafi, M., Sholl, L. M., Geffers, L., Alexander, B. & Santagata, S., 3 Sept 2018, In: Neuro-Oncology. 20, 10, p. 1331-1343 13 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Meningioma 100%
  • Cell Lineage 96%
  • Cues 80%
  • Transcription Factors 69%
  • Leptin Receptors 23%
  7 Citations (Scopus)

• The Luxembourg Parkinson's Study: A comprehensive approach for stratification and early diagnosis

  Hipp, G., Vaillant, M., Diederich, N. J., Roomp, K., Satagopam, V. P., Banda, P., Sandt, E., Mommaerts, K., Schmitz, S. K., Longhino, L., Schweicher, A., Hanff, A. M., Nicolai, B., Kolber, P., Reiter, D., Pavelka, L., Binck, S., Pauly, C., Geffers, L., Betsou, F., & 6 othersGantenbein, M., Klucken, J., Gasser, T., Hu, M. T., Balling, R. & Krüger, R., 2018, In: Frontiers in Aging Neuroscience. 10, 326.

  Research output: Contribution to journal › Article › Research › peer-review

  Open Access

  • Luxembourg 100%
  • Parkinson Disease 52%
  • Early Diagnosis 50%
  • Comorbidity 24%
  • Parkinsonian Disorders 22%
  34 Citations (Scopus)
• 2015

  A compendium of expression patterns of cholesterol biosynthetic enzymes in the mouse embryo

  Şişecioğlu, M., Budak, H., Geffers, L., Çankaya, M., Çiftci, M., Thaller, C., Eichele, G., Küfrevioğlu, Ö. İ. & Özdemir, H., Aug 2015, In: Journal of Lipid Research. 56, 8, p. 1551-9 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Cholesterol 100%
  • Embryonic Structures 91%
  • Enzymes 61%
  • Hedgehog Proteins 31%
  • Biosynthesis 20%

• High-throughput in situ hybridization: Systematical production of gene expression data and beyond

  Geffers, L. & Eichele, G., 2015, In: Neuromethods. 99, p. 221-245 25 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • RNA-Seq 100%
  • In Situ Hybridization 78%
  • Data Curation 64%
  • Gene Expression 51%
  • Pipeline 49%
  1 Citation (Scopus)

• Integrated annotation and analysis of in situ hybridization images using the ImAnno system: application to the ear and sensory organs of the fetal mouse

  Romand, R., Ripp, R., Poidevin, L., Boeglin, M., Geffers, L., Dollé, P. & Poch, O., 2015, In: PLoS ONE. 10, 2, p. e0118024

  Research output: Contribution to journal › Article › Research › peer-review

  • In Situ Hybridization 100%
  • Ear 96%
  • Genes 44%
  • Epithelium 41%
  • Molecular Sequence Annotation 36%
• 2014

  A computational approach to estimate interorgan metabolic transport in a mammal

  Cui, X., Geffers, L., Eichele, G. & Yan, J., 2014, In: PLoS ONE. 9, 6, p. e100963

  Research output: Contribution to journal › Article › Research › peer-review

  • Mammals 100%
  • Metabolic Networks and Pathways 75%
  • Homeostasis 27%
  • Gene Expression 22%
  3 Citations (Scopus)
• 2013

  METscout: a pathfinder exploring the landscape of metabolites, enzymes and transporters

  Geffers, L., Tetzlaff, B., Cui, X., Yan, J. & Eichele, G., Jan 2013, In: Nucleic Acids Research. 41, Database issue, p. D1047-54

  Research output: Contribution to journal › Article › Research › peer-review

  • Embryonic Structures 100%
  • Databases 73%
  • Gene Expression 73%
  • Enzymes 66%
  • Gene Regulatory Networks 66%
  7 Citations (Scopus)
• 2011

  A high-resolution anatomical atlas of the transcriptome in the mouse embryo

  Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., Magen, A., Canidio, E., Pagani, M., Peluso, I., Lin-Marq, N., Koch, M., Bilio, M., Cantiello, I., Verde, R., De Masi, C., Bianchi, S. A., Cicchini, J., Perroud, E., Mehmeti, S., & 48 othersDagand, E., Schrinner, S., Nürnberger, A., Schmidt, K., Metz, K., Zwingmann, C., Brieske, N., Springer, C., Hernandez, A. M., Herzog, S., Grabbe, F., Sieverding, C., Fischer, B., Schrader, K., Brockmeyer, M., Dettmer, S., Helbig, C., Alunni, V., Battaini, M-A., Mura, C., Henrichsen, C. N., Garcia-Lopez, R., Echevarria, D., Puelles, E., Garcia-Calero, E., Kruse, S., Uhr, M., Kauck, C., Feng, G., Milyaev, N., Ong, C. K., Kumar, L., Lam, M., Semple, C. A., Gyenesei, A., Mundlos, S., Radelof, U., Lehrach, H., Sarmientos, P., Reymond, A., Davidson, D. R., Dollé, P., Antonarakis, S. E., Yaspo, M-L., Martinez, S., Baldock, R. A., Eichele, G. & Ballabio, A., 18 Jan 2011, In: PLoS Biology. 9, 1, p. e1000582

  Research output: Contribution to journal › Article › Research › peer-review

  • topographic maps 100%
  • Atlases 88%
  • Transcriptome 75%
  • transcriptome 73%
  • Embryonic Structures 67%
  459 Citations (Scopus)
• 2010

  The transcription factor HNF1α regulates expression of chloride-proton exchanger ClC-5 in the renal proximal tubule

  Tanaka, K., Terryn, S., Geffers, L., Garbay, S., Pontoglio, M. & Devuyst, O., Dec 2010, In: American Journal of Physiology - Renal Physiology. 299, 6, p. F1339-47

  Research output: Contribution to journal › Article › Research › peer-review

  • Hepatocyte Nuclear Factor 1 100%
  • Proximal Kidney Tubule 76%
  • Chlorides 63%
  • Protons 61%
  • Kidney 32%
  14 Citations (Scopus)
• 2009

  CRX is a diagnostic marker of retinal and pineal lineage tumors

  Santagata, S., Maire, C. L., Idbaih, A., Geffers, L., Correll, M., Holton, K., Quackenbush, J. & Ligon, K. L., 20 Nov 2009, In: PLoS ONE. 4, 11, p. e7932

  Research output: Contribution to journal › Article › Research › peer-review

  • Pinealoma 100%
  • Retinoblastoma 23%
  • Neoplasms 22%
  • Transcription Factors 14%
  • RNA 13%
  38 Citations (Scopus)

• Expression patterns of the aquaporin gene family during renal development: influence of genetic variability

  Parreira, K. S., Debaix, H., Cnops, Y., Geffers, L. & Devuyst, O., Aug 2009, In: Pflugers Archiv European Journal of Physiology. 458, 4, p. 745-59 15 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Aquaporins 100%
  • Kidney 41%
  • Chain Reaction 38%
  • Marker 34%
  • Genes 31%
  20 Citations (Scopus)
• 2008

  Organization of the pronephric kidney revealed by large-scale gene expression mapping

  Raciti, D., Reggiani, L., Geffers, L., Jiang, Q., Bacchion, F., Subrizi, A. E., Clements, D., Tindal, C., Davidson, D. R., Kaissling, B. & Brändli, A. W., 2008, In: Genome Biology. 9, 5, p. R84

  Research output: Contribution to journal › Article › Research › peer-review

  • nephrons 100%
  • Chromosome Mapping 98%
  • gene expression 93%
  • Xenopus 66%
  • Nephrons 64%
  92 Citations (Scopus)
• 2004

  Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism

  Rabeler, R., Mittag, J., Geffers, L., Rüther, U., Leitges, M., Parlow, A. F., Visser, T. J. & Bauer, K., Jun 2004, In: Molecular endocrinology (Baltimore, Md.). 18, 6, p. 1450-60 11 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • mouse TRH-R1 protein 100%
  • Thyrotropin Releasing Hormone Receptors 66%
  • Hypothyroidism 42%
  • Animal Models 30%
  • Prolactin 23%
  66 Citations (Scopus)
• 2002

  A nuclear protein in Schizosaccharomyces pombe with homology to the human tumour suppressor Fhit has decapping activity

  Salehi, Z., Geffers, L., Vilela, C., Birkenhäger, R., Ptushkina, M., Berthelot, K., Ferro, M., Gaskell, S., Hagan, I., Stapley, B. & McCarthy, J. E. G., Oct 2002, In: Molecular Microbiology. 46, 1, p. 49-62 14 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Schizosaccharomyces 100%
  • Nuclear Proteins 86%
  • Protein Biosynthesis 45%
  • Fluorescence Microscopy 41%
  • histidine triad protein 39%
  26 Citations (Scopus)
• 2001

  A second elF4E protein in Schizosaccharomyces pombe has distinct elF4G-binding properties

  Ptushkina, M., Berthelot, K., Von der Haar, T., Geffers, L., Warwicker, J. & McCarthy, J. E. G., 15 Nov 2001, In: Nucleic Acids Research. 29, 22, p. 4561-4569 9 p.

  Research output: Contribution to journal › Article › Research › peer-review

  • Schizosaccharomyces pombe Proteins 100%
  • RNA Cap-Binding Proteins 75%
  • Schizosaccharomyces 73%
  • Ribosomes 15%
  • Amino Acid Sequence 14%
  33 Citations (Scopus)