Projects per year
Organisation profile
Organisation profile
Hypoxic stress in the tumor microenvironment is associated with tumor resistance to anti-cancer therapies. Hypoxia has been reported to play a key role in shielding tumour cells from immune cell attack either by promoting immune suppression, or by inducing many other oncogenic events and/or resistance mechanism (e.g. autophagy) in cancer cells, allowing tumour to escape from immune cell attack. We are interested in studying the molecular mechanism by which hypoxia allows cancer cells escape from immune surveillance and to investigate how targeting autophagy could improve cancer immunotherapy by switching the tumor microenvironment from immunosuppressive to immunopermissive for cytotoxic immune cells. Our collaboration with Gustave Roussy Cancer Center (France) allows us to conduct research at the interface between fundamental and clinically-oriented research programs.
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Collaborations and top research areas from the last five years
Profiles
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RADIO-D2R2: Radiomics for the differential diagnosis of radio-necrosis vs. progression after stereotactic radiotherapy of oligometastasis
Keunen, O. (PI), Vogin, G. (CoPI), Nazarov, P. (Partner), Zhang, L. (Participant) & Palissot, V. (Participant)
1/10/24 → 30/09/26
Project: Research
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INCEPTOR: Investigating the mode of action of ACB1801 on increasing TAP1 and improving cancer immunotherapy
Janji, B. (Scientific Advisor/Mentor) & Ramos, T. (PI)
1/04/24 → 31/03/26
Project: Research
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CombiN (Elisabetta Bartolini): Improving the Therapeutic benefit of immunotherapy in Neuroblastoma by combining autophagy inhibitor and anti-PD-i
Janji, B. (PI) & Bartolini, E. (PhD Student)
1/02/23 → 31/01/27
Project: Research
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Quantitative pre-clinical imaging of hypoxia and vascularity using MRI and PET
Kanli, G., Boudissa, S., Jirik, R., Adamsen, T., Espedal, H., Rolfsnes, H. O., Thorsen, F., Pacheco-Torres, J., Janji, B. & Keunen, O., 15 Jan 2025, Methods in Cell Biology. Academic Press Inc., Vol. 191. p. 289-328 (Methods in Cell Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy
Yu, Y., Bogdan, M., Noman, M. Z., Parpal, S., Bartolini, E., Van Moer, K., Kleinendorst, S. C., Bilgrav Saether, K., Trésaugues, L., Silvander, C., Lindström, J., Simeon, J., Timson, M. J., Al-Hashimi, H., Smith, B. D., Flynn, D. L., Alexeyenko, A., Viklund, J., Andersson, M. & Martinsson, J. & 3 others, , Aug 2024, In: Molecular Oncology. 18, 8, p. 1904-1922 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Identification of the role of HIF-1α-dependent hypoxia in the regulation of ACKR2 (Atypical Chemokine Receptor 2) expression in cancer
Benoit, A., 26 Jun 2024, Nancy: Université de Lorraine.Research output: Types of Thesis › Doctoral Thesis