Translational Radiomics

2024

Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles

Merz, M. P., Seal, S. V., Grova, N., Mériaux, S., Guebels, P., Kanli, G., Mommaerts, E., Nicot, N., Kaoma, T., Keunen, O., Nazarov, P. V. & Turner, J. D., 11 Mar 2024, In: Scientific Reports. 14, 1, 5898.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

2023

Immune cell identity behind the Ktrans mapping of mouse glioblastoma

Zhang, Y., Keunen, O., Golebiewska, A., Gerosa, M., Wang, J., Ghobadi, S. N., Huang, A., Hou, Q., Habte, F. G., Li, N., Grant, G., Paulmurugan, R., Lee, K. S. & Wintermark, M., Nov 2023, In: Magnetic Resonance Imaging. 103, p. 92-101 10 p.

Research output: Contribution to journal › Article › Research › peer-review

Molecular Identity Changes of Tumor-Associated Macrophages and Microglia After Magnetic Resonance Imaging–Guided Focused Ultrasound–Induced Blood–Brain Barrier Opening in a Mouse Glioblastoma Model

Zhang, Y., Wang, J., Ghobadi, S. N., Zhou, H., Huang, A., Gerosa, M., Hou, Q., Keunen, O., Golebiewska, A., Habte, F. G., Grant, G. A., Paulmurugan, R., Lee, K. S. & Wintermark, M., May 2023, In: Ultrasound in Medicine and Biology. 49, 5, p. 1082-1090 9 p.

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

2022

Federated learning enables big data for rare cancer boundary detection

Pati, S., Baid, U., Edwards, B., Sheller, M., Wang, S. H., Reina, G. A., Foley, P., Gruzdev, A., Karkada, D., Davatzikos, C., Sako, C., Ghodasara, S., Bilello, M., Mohan, S., Vollmuth, P., Brugnara, G., Preetha, C. J., Sahm, F., Maier-Hein, K. & Zenk, M. & 259 others, Bendszus, M., Wick, W., Calabrese, E., Rudie, J., Villanueva-Meyer, J., Cha, S., Ingalhalikar, M., Jadhav, M., Pandey, U., Saini, J., Garrett, J., Larson, M., Jeraj, R., Currie, S., Frood, R., Fatania, K., Huang, R. Y., Chang, K., Quintero, C. B., Capellades, J., Puig, J., Trenkler, J., Pichler, J., Necker, G., Haunschmidt, A., Meckel, S., Shukla, G., Liem, S., Alexander, G. S., Lombardo, J., Palmer, J. D., Flanders, A. E., Dicker, A. P., Sair, H. I., Jones, C. K., Venkataraman, A., Jiang, M., So, T. Y., Chen, C., Heng, P. A., Dou, Q., Kozubek, M., Lux, F., Michálek, J., Matula, P., Keřkovský, M., Kopřivová, T., Dostál, M., Vybíhal, V., Vogelbaum, M. A., Mitchell, J. R., Farinhas, J., Maldjian, J. A., Yogananda, C. G. B., Pinho, M. C., Reddy, D., Holcomb, J., Wagner, B. C., Ellingson, B. M., Cloughesy, T. F., Raymond, C., Oughourlian, T., Hagiwara, A., Wang, C., To, M. S., Bhardwaj, S., Chong, C., Agzarian, M., Falcão, A. X., Martins, S. B., Teixeira, B. C. A., Sprenger, F., Menotti, D., Lucio, D. R., LaMontagne, P., Marcus, D., Wiestler, B., Kofler, F., Ezhov, I., Metz, M., Jain, R., Lee, M., Lui, Y. W., McKinley, R., Slotboom, J., Radojewski, P., Meier, R., Wiest, R., Murcia, D., Fu, E., Haas, R., Thompson, J., Ormond, D. R., Badve, C., Sloan, A. E., Vadmal, V., Waite, K., Colen, R. R., Pei, L., Ak, M., Srinivasan, A., Bapuraj, J. R., Rao, A., Wang, N., Yoshiaki, O., Moritani, T., Turk, S., Lee, J., Prabhudesai, S., Morón, F., Mandel, J., Kamnitsas, K., Glocker, B., Dixon, L. V. M., Williams, M., Zampakis, P., Panagiotopoulos, V., Tsiganos, P., Alexiou, S., Haliassos, I., Zacharaki, E. I., Moustakas, K., Kalogeropoulou, C., Kardamakis, D. M., Choi, Y. S., Lee, S. K., Chang, J. H., Ahn, S. S., Luo, B., Poisson, L., Wen, N., Tiwari, P., Verma, R., Bareja, R., Yadav, I., Chen, J., Kumar, N., Smits, M., van der Voort, S. R., Alafandi, A., Incekara, F., Wijnenga, M. M. J., Kapsas, G., Gahrmann, R., Schouten, J. W., Dubbink, H. J., Vincent, A. J. P. E., van den Bent, M. J., French, P. J., Klein, S., Yuan, Y., Sharma, S., Tseng, T. C., Adabi, S., Niclou, S. P., Keunen, O., Hau, A. C., Vallières, M., Fortin, D., Lepage, M., Landman, B., Ramadass, K., Xu, K., Chotai, S., Chambless, L. B., Mistry, A., Thompson, R. C., Gusev, Y., Bhuvaneshwar, K., Sayah, A., Bencheqroun, C., Belouali, A., Madhavan, S., Booth, T. C., Chelliah, A., Modat, M., Shuaib, H., Dragos, C., Abayazeed, A., Kolodziej, K., Hill, M., Abbassy, A., Gamal, S., Mekhaimar, M., Qayati, M., Reyes, M., Park, J. E., Yun, J., Kim, H. S., Mahajan, A., Muzi, M., Benson, S., Beets-Tan, R. G. H., Teuwen, J., Herrera-Trujillo, A., Trujillo, M., Escobar, W., Abello, A., Bernal, J., Gómez, J., Choi, J., Baek, S., Kim, Y., Ismael, H., Allen, B., Buatti, J. M., Kotrotsou, A., Li, H., Weiss, T., Weller, M., Bink, A., Pouymayou, B., Shaykh, H. F., Saltz, J., Prasanna, P., Shrestha, S., Mani, K. M., Payne, D., Kurc, T., Pelaez, E., Franco-Maldonado, H., Loayza, F., Quevedo, S., Guevara, P., Torche, E., Mendoza, C., Vera, F., Ríos, E., López, E., Velastin, S. A., Ogbole, G., Soneye, M., Oyekunle, D., Odafe-Oyibotha, O., Osobu, B., Shu’aibu, M., Dorcas, A., Dako, F., Simpson, A. L., Hamghalam, M., Peoples, J. J., Hu, R., Tran, A., Cutler, D., Moraes, F. Y., Boss, M. A., Gimpel, J., Veettil, D. K., Schmidt, K., Bialecki, B., Marella, S., Price, C., Cimino, L., Apgar, C., Shah, P., Menze, B., Barnholtz-Sloan, J. S., Martin, J. & Bakas, S., 5 Dec 2022, In: Nature Communications. 13, 1, 7346.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

106 Citations (Scopus)

The BET Protein Inhibitor JQ1 Decreases Hypoxia and Improves the Therapeutic Benefit of Anti-PD-1 in a High-Risk Neuroblastoma Mouse Model

Sauvage, D., Bosseler, M., Viry, E., Kanli, G., Oudin, A., Berchem, G., Keunen, O. & Janji, B., 6 Sept 2022, In: Cells. 11, 18, 2783.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)

2021

Non-invasive, neurotoxic surgery reduces seizures in a rat model of temporal lobe epilepsy

Zhang, Y., Buckmaster, P. S., Qiu, L., Wang, J., Keunen, O., Ghobadi, S. N., Huang, A., Hou, Q., Li, N., Narang, S., Habte, F. G., Bertram, E. H., Lee, K. S. & Wintermark, M., Sept 2021, In: Experimental Neurology. 343, p. 113761 113761.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

6 Citations (Scopus)

Protocol for derivation of organoids and patient-derived orthotopic xenografts from glioma patient tumors

Oudin, A., Baus, V., Barthelemy, V., Fabian, C., Klein, E., Dieterle, M., Wantz, M., Hau, A. C., Dording, C., Bernard, A., Michelucci, A., Yabo, Y. A., Kanli, G., Keunen, O., Bjerkvig, R., Niclou, S. P. & Golebiewska, A., 18 Jun 2021, In: STAR Protocols. 2, 2, p. 100534 100534.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

13 Citations (Scopus)

2020

Patient-derived organoids and orthotopic xenografts of primary and recurrent gliomas represent relevant patient avatars for precision oncology

Golebiewska, A., Hau, A. C., Oudin, A., Stieber, D., Yabo, Y. A., Baus, V., Barthelemy, V., Klein, E., Bougnaud, S., Keunen, O., Wantz, M., Michelucci, A., Neirinckx, V., Muller, A., Kaoma, T., Nazarov, P. V., Azuaje, F., De Falco, A., Flies, B. & Richart, L. & 21 others, Poovathingal, S., Arns, T., Grzyb, K., Mock, A., Herold-Mende, C., Steino, A., Brown, D., May, P., Miletic, H., Malta, T. M., Noushmehr, H., Kwon, Y. J., Jahn, W., Klink, B., Tanner, G., Stead, L. F., Mittelbronn, M., Skupin, A., Hertel, F., Bjerkvig, R. & Niclou, S. P., Dec 2020, In: Acta Neuropathologica. 140, 6, p. 919-949 31 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

77 Citations (Scopus)

2019

Improved drug delivery to brain metastases by peptide-mediated permeabilization of the blood–brain barrier

Aasen, S. N., Espedal, H., Holte, C. F., Keunen, O., Karlsen, T. V., Tenstad, O., Maherally, Z., Miletic, H., Hoang, T., Eikeland, A. V., Baghirov, H., Olberg, D. E., Pilkington, G. J., Sarkar, G., Jenkins, R. B., Sundstrøm, T., Bjerkvig, R. & Thorsen, F., Nov 2019, In: Molecular Cancer Therapeutics. 18, 11, p. 2171-2181 11 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)

Spatially regularized estimation of the tissue homogeneity model parameters in DCE-MRI using proximal minimization

Bartoš, M., Rajmic, P., Šorel, M., Mangová, M., Keunen, O. & Jiřík, R., 1 Dec 2019, In: Magnetic Resonance in Medicine. 82, 6, p. 2257-2272 16 p.

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

2018

EGFL7 enhances surface expression of integrin α ₅ β ₁ to promote angiogenesis in malignant brain tumors

Dudvarski Stanković, N., Bicker, F., Keller, S., Jones, D. T. W., Harter, P. N., Kienzle, A., Gillmann, C., Arnold, P., Golebiewska, A., Keunen, O., Giese, A., von Deimling, A., Bäuerle, T., Niclou, S. P., Mittelbronn, M., Ye, W., Pfister, S. M. & Schmidt, M. H. H., Sept 2018, In: EMBO Molecular Medicine. 10, 9, e8420.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

36 Citations (Scopus)

Lack of functional normalisation of tumour vessels following anti-angiogenic therapy in glioblastoma

Obad, N., Espedal, H., Jirik, R., Sakariassen, P. O., Brekke Rygh, C., Lund-Johansen, M., Taxt, T., Niclou, S. P., Bjerkvig, R. & Keunen, O., 1 Oct 2018, In: Journal of Cerebral Blood Flow and Metabolism. 38, 10, p. 1741-1753 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

15 Citations (Scopus)

2017

Altered metabolic landscape in IDH-mutant gliomas affects phospholipid, energy, and oxidative stress pathways

Fack, F., Tardito, S., Hochart, G., Oudin, A., Zheng, L., Fritah, S., Golebiewska, A., Nazarov, P. V., Bernard, A., Hau, A. C., Keunen, O., Leenders, W., Lund-Johansen, M., Stauber, J., Gottlieb, E., Bjerkvig, R. & Niclou, S. P., Dec 2017, In: EMBO Molecular Medicine. 9, 12, p. 1681-1695 15 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

101 Citations (Scopus)

Subtraction of subcutaneous fat to improve the prediction of visceral adiposity: exploring a new anthropometric track in overweight and obese youth

Samouda, H., De Beaufort, C., Stranges, S., Van Nieuwenhuyse, J. P., Dooms, G., Keunen, O., Leite, S., Vaillant, M., Lair, M. L. & Dadoun, F., Aug 2017, In: Pediatric Diabetes. 18, 5, p. 399-404 6 p.

Research output: Contribution to journal › Article › Research › peer-review

5 Citations (Scopus)

2016

Cardiometabolic risk: Leg fat is protective during childhood

Samouda, H., De Beaufort, C., Stranges, S., Hirsch, M., Van Nieuwenhuyse, J. P., Dooms, G., Gilson, G., Keunen, O., Leite, S., Vaillant, M., Lair, M. L. & Dadoun, F., 1 Jun 2016, In: Pediatric Diabetes. 17, 4, p. 300-308 9 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

17 Citations (Scopus)

EGFRvIII mutations can emerge as late and heterogenous events in glioblastoma development and promote angiogenesis through Src activation

Eskilsson, E., Rosland, G. V., Talasila, K. M., Knappskog, S., Keunen, O., Sottoriva, A., Foerster, S., Solecki, G., Taxt, T., Jirik, R., Fritah, S., Harter, P. N., Välk, K., Al Hossain, J., Joseph, J. V., Jahedi, R., Saed, H. S., Piccirillo, S. G., Spiteri, I. & Euskirchen, P. & 10 others, Graziani, G., Daubon, T., Lund-Johansen, M., Enger, P. Ø., Winkler, F., Ritter, C. A., Niclou, S. P., Watts, C., Bjerkvig, R. & Miletic, H., Dec 2016, In: Neuro-Oncology. 18, 12, p. 1644-1655 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

80 Citations (Scopus)

Molecular crosstalk between tumour and brain parenchyma instructs histopathological features in glioblastoma

Bougnaud, S., Golebiewska, A., Oudin, A., Keunen, O., Harter, P. N., Mäder, L., Azuaje, F., Fritah, S., Stieber, D., Kaoma, T., Vallar, L., Brons, N. H. C., Daubon, T., Miletic, H., Sundstrøm, T., Herold-Mende, C., Mittelbronn, M., Bjerkvig, R. & Niclou, S. P., 31 May 2016, In: Oncotarget. 7, 22, p. 31955-31971 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

61 Citations (Scopus)

2015

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas

Fack, F., Espedal, H., Keunen, O., Golebiewska, A., Obad, N., Harter, P. N., Mittelbronn, M., Bähr, O., Weyerbrock, A., Stuhr, L., Miletic, H., Sakariassen, P., Stieber, D., Rygh, C. B., Lund-Johansen, M., Zheng, L., Gottlieb, E., Niclou, S. P. & Bjerkvig, R., 17 Jan 2015, In: Acta Neuropathologica. 129, 1, p. 115-131 17 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

115 Citations (Scopus)

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma

Tardito, S., Oudin, A., Ahmed, S. U., Fack, F., Keunen, O., Zheng, L., Miletic, H., Sakariassen, P. Ø., Weinstock, A., Wagner, A., Lindsay, S. L., Hock, A. K., Barnett, S. C., Ruppin, E., Harald MØrkve, S., Lund-Johansen, M., Chalmers, A. J., Bjerkvig, R., Niclou, S. P. & Gottlieb, E., 27 Nov 2015, In: Nature Cell Biology. 17, 12, p. 1556-1568 13 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access

407 Citations (Scopus)

Translational Radiomics

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