Translational Medicine Operations Hub

Projects

Projects per year 2010 2016 2020 2021 2028

• 17 Active
• 23 Finished

Projects per year

Search results

• Active

  NVDX3-CLN01: Safety and efficacy of Novadip 3D osteogenic implants

  Alexandre, M.

  1/08/23 → 31/12/25

  Project: Consultancy

• NVDX3-spine: Safety and efficacy of Novadip autologous 3D osteogenic implant in the treatment of recalcitrant limb nonunion

  Gantenbein, M. & Alexandre, M.

  1/07/23 → 30/06/25

  Project: Consultancy

• PPS: Validation of the Point Prevalence Survey of healthcare-associated infections and antimicrobial use in acute care hospitals in Luxembourg

  Alexandre, M.

  ECDC

  1/04/23 → 30/09/23

  Project: Consultancy

• IPerGlio: Improving personalized glioblastoma care by intertwined immunomics and artificial intelligence approaches

  Cosma, A. & Nazarov, P.

  FNR - Fonds National de la Recherche

  1/04/23 → 31/03/26

  Project: Research

• QTrobot: QTrobot - a digital therapeutic device for in-home therapy of children with autism

  Gantenbein, M., Klucken, J. & Alexandre, M.

  FNR - Fonds National de la Recherche

  1/07/22 → 31/12/24

  Project: Research

  • Autistic Disorder 100%
  • Child 49%
  • Equipment and Supplies 39%
  • Luxembourg 29%
  • Parents 20%

• I2TRON Naphisabet Wanniang: Markers of shaping and educating the early life immune response to food proteins

  Kuehn, A. & Wanniang, N.

  FNR - Fonds National de la Recherche

  1/04/22 → 31/03/26

  Project: Research

• EXPO: ExpoBiome – Deciphering the impact of exposures from the gut microbiome-derived molecular complex in human health and disease

  Thien, H.

  University of Luxembourg

  10/03/22 → 31/12/24

  Project: Consultancy

  • Luxembourg 100%
  • biorefining 75%
  • human diseases 71%
  • microbiome 64%
  • cytokines 62%

• CONVINCE-ORCHESTRA

  Bulaev, D.

  1/01/22 → 31/12/23

  Project: Research

• EPND: European platform for neurodegenerative disorders

  Marchese, M.

  European Commission

  1/11/21 → 31/10/26

  Project: Research

  • Alzheimer Disease 100%
  • Neurodegenerative Diseases 83%
  • Biomarkers 83%
  • Parkinson Disease 80%
  • Formal Social Control 32%

• GPD4: Global Platform for the Prevention of Autoimmune Diabetes

  Thien, H.

  Helmsley Trust

  1/11/21 → 31/10/28

  Project: Consultancy

  • Type 1 Diabetes Mellitus 100%

• MelCol_PFP: PERSONAL FUNCTIONAL PROFILING FOR DRUG DISCOVERY IN MELANOMA AND COLORECTAL CANCER

  El Khoury, V. & Cutrona, M.

  FNR - Fonds National de la Recherche

  1/04/21 → 31/03/25

  Project: Research

• MiniMox: A randomised parallel-group pharmacokinetic study to evaluate the bioequivalence of different formulations of moxidectin in adults

  Vaillant, M., Sullivan, M., Batchelor, H. & Opoku, N. O.

  FNR - Fonds National de la Recherche, European and Developing Countries Clinical Trials Partnership (EDCTP)

  1/01/21 → 30/07/25

  Project: Research

  • milbemycin 100%
  • Therapeutic Equivalency 54%
  • Pharmacokinetics 32%
  • Tablets 30%
  • Biological Availability 20%

• EATRIS-Plus: Consolidating the capacities of EATRIS-ERIC for Personalised Medicine

  Ammerlaan, W., Marchese, M., Beaumont, K. & Nazarov, P.

  European Commission

  1/10/20 → 1/12/23

  Project: Research

• 5FC HIV-Crypto: Improved flucytosine formulation for the treatment of meningitis in advanced HIV disease

  Vaillant, M., Ribeiro, I., Loyse, A., Godfrey, S., Theron, H. B. & Kanyama, C.

  FNR - Fonds National de la Recherche

  1/04/20 → 31/12/24

  Project: Research

  • Cryptococcal Meningitis 100%
  • Flucytosine 83%
  • Meningitis 53%
  • HIV 48%
  • acifluorfen 35%

• MIMVac-Africa: A multilateral initiative to foster the clinical development of effective malaria vaccine candidates in Africa

  Vaillant, M., Sirima, S. B., Agnandji, S. T., Aide, P., Olotu, A., Ndungu, F., Yazdanbakhsh, M., Viebig, N., Hill, A., Draper, S., Kremsner, P. G., Corradin, G., Horii, T. & Hoffman, S.

  FNR - Fonds National de la Recherche

  1/02/20 → 31/01/25

  Project: Research

  • Malaria Vaccines 100%
  • Malaria 29%
  • Vaccines 24%
  • Infections 22%
  • Multicenter Studies 13%

• MoxiMultiDoseMod: Moxidectin for accelerating onchocerciasis elimination: A paediatric dose-finding study, a phase 3b trialc omparing efficacy and safety of annual and biannual moxidectin or ivermectin treatment and mathematical modelling of moxidectin and ivermectin based elimination strategies to support country policy decision

  Vaillant, M., Sullivan, M., Ukety, T., Mandro, M., Stolk, W., Basáñez, M., Kuesel, A. C., Walker, M., Colebunders, R. & Opoku, N. O.

  FNR - Fonds National de la Recherche, European and Developing Countries Clinical Trials Partnership (EDCTP)

  1/08/19 → 30/11/24

  Project: Research

  • milbemycin 100%
  • Onchocerciasis 74%
  • Ivermectin 65%
  • Safety 27%
  • Pediatrics 27%

• ECRIN: European Clinical Research Infrastructure Network

  Gantenbein, M. & Montanes, G.

  ecrin - European Research Infrastruture Consortium

  1/01/15 → …

  Project: Research

  • Luxembourg 100%
  • Ethics 94%
  • Pharmacovigilance 80%
  • Nonprofit Organizations 46%
  • Clinical Studies 43%
• Finished

  Optimized Multicolor Immunofluorescence Panel (OMIP) Database

  Cosma, A., Hedin, F. & Wang, W.

  1/09/21 → 31/08/22

  Project: Other

  • Antibodies 100%
  • Competitive intelligence 99%

• PIMP-GBM: Prognostic Impact of Monocyte subsets in Patients with Glioblastoma

  Michelucci, A., Skupin, A. & Betsou, F.

  Personalised Medicine Consortium (PMC)

  1/01/21 → 31/12/22

  Project: Research

  • Glioblastoma 100%
  • Monocytes 72%
  • Neoplasms 43%
  • Immunotherapy 23%
  • Cellular Microenvironment 16%

• unCoVer: Unravelling Data for Rapid Evidence-Based Response to COVID-19

  Vaillant, M., Huiart, L. & Fagherazzi, G.

  European Commission

  15/11/20 → 15/11/22

  Project: Research

  • Safety 100%
  • Disease Outbreaks 75%
  • Datasets 67%
  • Comorbidity 67%
  • Public Health 61%

• SCOL: Assessing the Pharmacokinetics, Safety, Tolerability and Efficacy of Continuous Oral Levodopa via the DopaFuse® Delivery System in Parkinson’s Disease Patients

  Krüger, R., Thien, H. & McIntyre, D.

  1/11/20 → 30/09/22

  Project: Consultancy

• COV-Array: Coronavirus antigen array for parallelized serological profiling

  Longworth, J. & Dittmar, G.

  FNR - Fonds National de la Recherche

  1/07/20 → 28/02/21

  Project: Research

  • Coronavirinae 100%
  • antigens 75%
  • antibodies 62%
  • antibody formation 26%
  • immunoglobulins 26%

• RAS CoV-2: Peptide / protein /single-cell map of the renin-angiotensin system in Covid-19

  Cosma, A.

  FNR - Fonds National de la Recherche

  1/05/20 → 28/02/21

  Project: Research

  • Renin-Angiotensin System 100%
  • single cell proteins 98%
  • SARS Virus 63%
  • Peptides 43%
  • Immune System 34%

• CON-VINCE: COvid-19 National survey for assessing Viral spread by Non-affected Carriers

  Krüger, R., Satagopam, V. P., Huiart, L., Ollert, M., Berchem, G., Betsou, F., Brenner, D., Gantenbein, M., Vaillant, M., Turner, J., Aguayo, G., Vaillant, M., Bahlawane, C., Roomp, K., Hübschen, J. & Snoeck, C.

  FNR - Fonds National de la Recherche

  1/04/20 → 31/12/21

  Project: Research

  • Luxembourg 100%
  • SARS Virus 73%
  • national surveys 59%
  • Social Determinants of Health 44%
  • Pandemics 44%

• PARK-QC (Chiara Romano): Molecular, Organellar and Cellular Quality Control in Parkinson's disease and other Neurodegenerative Diseases

  Mathieson, W.

  FNR - Fonds National de la Recherche

  1/02/20 → 31/05/21

  Project: Research

• PEVOdata: Data solutions based on a basket prospective trial with pembrolizumab and Vorinostat in patients with late stage squamous cell carcinoma

  Thien, H. & Betsou, F.

  FNR - Fonds National de la Recherche

  25/06/19 → 24/06/23

  Project: Research

• CANBIO (Hugo Dosquet): Development of methodologies for monitoring cancer progression and predicting treatment response

  Azuaje, F. & Dosquet, H.

  FNR - Fonds National de la Recherche

  1/01/19 → 31/12/22

  Project: Research

  • Monitoring 100%

• 180297_PROMI: Development of a novel microbiota-based therapy for the prevention of type 2 diabetes mellitus

  Marchese, M.

  FNR - Fonds National de la Recherche

  1/05/18 → 30/04/22

  Project: Research

• PFP: Personal Functional Profiling

  Kwon, Y., Mao, X. & Michel, T.

  23/04/18 → 22/04/21

  Project: Research

  • Luxembourg 100%
  • Pharmaceutical Preparations 64%
  • Neoplasms 60%
  • Gastrointestinal Neoplasms 37%
  • Precision Medicine 33%

• DEMICS: Decomposition of mixed transcriptomes for classification of heterogeneous tumour samples

  Nazarov, P.

  FNR - Fonds National de la Recherche

  1/01/18 → 31/01/21

  Project: Research

  • Genes 100%
  • Transcriptome 86%
  • Glioblastoma 66%
  • Tumors 65%
  • Independent component analysis 64%

• APSIS: Allergen Peptide SIgnatureS in allergic vs tolerant individuals (APSIS): paving the way for novel personalized medicine approaches to diagnose and cure food allergies

  Kuehn, A., Schneider, R. & Ammerlaan, W.

  Personalised Medicine Consortium (PMC)

  1/01/18 → 30/11/20

  Project: Research

  • Food Hypersensitivity 100%
  • Allergens 87%
  • Precision Medicine 66%
  • Food 65%
  • Peptides 44%

• Chair in Neuropathology: NPath

  Niclou, S., Balling, R. & Mittelbronn, M.

  FNR - Fonds National de la Recherche

  1/01/17 → 31/12/22

  Project: Research

  • Glioma 100%
  • Glioblastoma 92%
  • Microglia 40%
  • Neoplasms 34%
  • Synucleins 32%

• NoStra: New strategies for assessing exposure to endocrine disruptor's rapid elimination by analysis of non-invasive biological samples

  Appenzeller, B., Vaillant, M., Haan, S. & Fays, F.

  FNR - Fonds National de la Recherche, Institut national de la santé et de la recherche médicale

  1/10/16 → 30/11/21

  Project: Research

  • endocrine disruptor 100%
  • Endocrine Disruptor 94%
  • urine 78%
  • Biological Marker 68%
  • biomarker 64%

• GDMP: Development of a Good Data Management Practices (GDMP) training course

  Vaillant, M.

  WHO

  1/06/16 → 31/12/18

  Project: Consultancy

  • managers 100%
  • education programs 93%
  • operations research 51%
  • Luxembourg 50%
  • income 43%

• ACTIVE TB: Data management of global aDSM database in the scope of active TB drug-safety monitoring

  Vaillant, M.

  WHO

  1/05/16 → 31/03/19

  Project: Consultancy

  • data management 100%
  • safety 97%
  • drug 93%
  • monitoring 60%

• aDSM TB: Development and hosting of central database platform for collection of safety data in the scope of active TB drug-safety monitoring

  Vaillant, M.

  WHO

  1/05/16 → 31/01/20

  Project: Consultancy

  • Drug Monitoring 100%
  • Multidrug-Resistant Tuberculosis 93%
  • Databases 72%
  • Safety 67%
  • Data Curation 58%

• Action des HDACis-IMiDs dans le MM: Impact of the immunomodulatory effect of the combination HDACis/IMiDs in myelome multiple (MM).

  Janji, B., Berchem, G., Aouali, N. & Giuliani, M.

  FNRS - Fonds National de la Recherche Scientifique

  15/01/16 → 14/01/18

  Project: Research

  • Natural Killer Cells 100%
  • Immune System 85%
  • Pharmaceutical Preparations 71%
  • Exocytosis 48%
  • Histone Deacetylase Inhibitors 25%

• Anthelmintic: Data Analysis of Response to Anthelmintic Treatment

  Vaillant, M.

  WHO

  30/11/15 → 31/12/17

  Project: Consultancy

• Memo Lingua: Exploration of the neuroprotective benefit provided by multilingualism acting as proxy for cognitive reserve in the prevention of cognitive impairment and decline

  Perquin, M., Caldarelli, N. & Vaillant, M.

  Luxembourg Institute of Health (LIH)

  1/01/15 → 31/12/17

  Project: Research

• CPIL: Clinical Proteomics Initiative Luxembourg

  Dittmar, G. & Domon, B.

  FNR - Fonds National de la Recherche

  1/10/10 → 31/12/17

  Project: Research

  • Proteomics 100%
  • flight simulation 66%
  • proteome 64%
  • MARS (Manned Reusable Spacecraft) 57%
  • urine 47%