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Translational & Clinical Immunology

Organisation profile

Organisation profile

The Translational and Clinical Immunology group aims to discover novel molecular and cellular intervention candidates and identify diagnostic and prognostic biomarkers for non-communicable complex diseases and infectious diseases, by integrating both pre-clinical animal models and human samples from cohorts and clinical trials. The overall research topics of the group are divided into the following specific themes:

1. Identify novel mechanisms leading to immune tolerance through allergen-specific immunotherapies used for treating various allergic diseases (led by Prof. Markus Ollert).

2. Investigate the potential links between acute viral infection, host immune dysregulations and the subsequent development of autoimmune, allergic and neurological disorders (led by Prof. Markus Ollert).

3. Identify the molecular mechanisms underlying the immune ageing process and their implementation in ageing-associated diseases (led by Dr. Feng Hefeng).

4. Develop and apply cutting-edge deep immunophenotyping strategies to enhance the understanding of immune dysregulations in various complex and infectious diseases (led by Dr. Feng Hefeng).

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  • Converging Pathomechanisms Link SARS-CoV-2 Infection With Major Neurodegenerative Diseases

    Hefeng, F. Q., Marti-Sarrias, A., Guvenilir, H. A., Vieira de Sa, R., Sridhar, A., Haferkamp, U., El Kach-Marso, F., Bauermeister, S., Hudak, A., Roubanis, A., Ohnmacht, J., Sethumadhava, P., Ollert, M., Hofmann-Apitius, M., Navarro, A., Kodamullil, A. T., Pless, O., Letoha, T., Acosta, S. & Krüger, R., 27 Feb 2026, 67 p.

    Research output: Working paper › Preprint

  • Stepwise single-cell-resolved deep immunophenotyping pipeline to characterize immune heterogeneity and functionality in health and disease

    Roubanis, A., Mei, Z., Hedin, F., Ammerlaan, W., Ollert, M., Cosma, A. & Hefeng, F. Q., 29 Jan 2026, 26 p.

    Research output: Working paper › Preprint

  • Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study

    Sousa-Pinto, B., Louis, R., Anto, J. M., Amaral, R., Sá-Sousa, A., Czarlewski, W., Brussino, L., Canonica, G. W., Chaves Loureiro, C., Cruz, A. A., Gemicioglu, B., Haahtela, T., Kupczyk, M., Kvedariene, V., Larenas-Linnemann, D. E., Okamoto, Y., Ollert, M., Pfaar, O., Pham-Thi, N. & Puggioni, F. & 49 others, Regateiro, F. S., Romantowski, J., Sastre, J., Scichilone, N., Taborda-Barata, L., Ventura, M. T., Agache, I., Bedbrook, A., Becker, S., Bergmann, K. C., Bosnic-Anticevich, S., Bonini, M., Boulet, L. P., Brusselle, G., Buhl, R., Cecchi, L., Charpin, D., de Blay, F., Del Giacco, S., Ivancevich, J. C., Jutel, M., Klimek, L., Kraxner, H., Kuna, P., Laune, D., Makela, M., Morais-Almeida, M., Nadif, R., Niedoszytko, M., Papadopoulos, N. G., Papi, A., Patella, V., Pétré, B., Rivero Yeverino, D., Robalo Cordeiro, C., Roche, N., Rouadi, P. W., Samolinski, B., Savouré, M., Shamji, M. H., Sheikh, A., Suppli Ulrik, C., Usmani, O. S., Valiulis, A., Yorgancioglu, A., Zuberbier, T., Fonseca, J. A., Costa, E. M. & Bousquet, J., 31 Dec 2025, In: Pulmonology. 31, 1, 2416869.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    15 Citations (Scopus)
View all 226 research outputs