Projects per year
Organisation profile
Organisation profile
Our research focuses on understanding how our changing dietary habits, especially the reduced consumption of dietary fiber, impacts susceptibility to various diseases such as inflammatory bowel diseases, multiple sclerosis and allergy, as well as to a variety of gastrointestinal pathogens. We investigate the microbiome-mediated molecular mechanisms that impact our immune system via the interaction with the colonic mucus barrier, which is one of the first lines of host defense. In order to effectively address our research questions, we utilize a variety of tools and techniques from high-throughput culturing of commensal gut bacteria to next-generation sequencing, as well as immunological tools like mass cytometry (CyTOF).
Our research exploits the power of synthetic human gut microbiotas in various gnotobiotic mouse models of the multiple diseases. Importantly, we also incorporate translational approaches to shift findings from a mouse model to human cohorts in order to inform clinical care or public health measures related to dietary fiber intake and disease.
The mission of our research is to pursue the “from bed to bench to bed” approach to explore the disease-based biomarkers and susceptibility factors that could be used as critical transition points between health and disease in order to harness the potential of microbiome engineering.
Former name of the Research Group: Eco-Immunology and Microbiome (01/01/2015-31/07/2023)
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Collaborations and top research areas from the last five years
Profiles
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I2TRON Mihovil Joja: Mucin-degrading bacteria in ulcerative colitis: a translational approach
Desai, M. (PI) & Joja, M. (PhD Student)
1/06/23 → 31/05/26
Project: Research
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CAROFIBER: Interactions of carotenoids and dietary fiber – implications for bioavailability and colonic degradation
Bohn, T. (PI), Desai, M. (Partner) & Shukla, A. (PhD Student)
FNR - Fonds National de la Recherche
1/05/23 → 31/07/26
Project: Research
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HealthyW8: Empowering Healthy Lifestyle Behaviour Through Personalized Intervention Portfolios To Prevent And Control Obesity During Vulnerable Stages Of Life
Bohn, T. (PI), Vahid, F. (Partner), Desai, M. (Partner), Turner, J. (Partner), Devaux, Y. (Partner) & Malisoux, L. (Partner)
1/05/23 → 30/04/28
Project: Research
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A blueprint for contemporary studies of microbiomes
Bindels, L. B., Watts, J. E. M., Theis, K. R., Carrion, V. J., Ossowicki, A., Seifert, J., Oh, J., Shao, Y., Hilty, M., Kumar, P., Hildebrand, F., Lovejoy, C., Wigley, P., Yu, K., Zhang, M., Zhang, T., Walter, J., Desai, M. S., Huws, S. A. & Schriml, L. M. & 5 others, , 8 Apr 2025, In: Microbiome. 13, 1, 9 p., 95.Research output: Contribution to journal › Editorial
Open Access -
A Consensus Statement on establishing causality, therapeutic applications and the use of preclinical models in microbiome research
Metwaly, A., Kriaa, A., Hassani, Z., Carraturo, F., Druart, C., Pinto, F., Asnicar, F., Segata, N., Morozova, V., Sarathi, A., Arumugam, M., Boucher, K., Loftus, S., Shkoporov, A., Hill, C., Joos, R., Claesson, M., Lavelle, A., O’Toole, P. & Ross, P. & 32 others, , May 2025, In: Nature Reviews Gastroenterology and Hepatology. 22, 5, p. 343-356 14 p., 103.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Non-SCFA microbial metabolites associated with fiber fermentation and host health
Grant, E. T., De Franco, H. & Desai, M. S., Jan 2025, In: Trends in Endocrinology and Metabolism. 36, 1, p. 70-82 13 p.Research output: Contribution to journal › Review article › peer-review
Open Access6 Citations (Scopus)
Equipment
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AllenTown SC Plus Biological Safety Cabinet
Desai, M. (Manager)
Nutrition, Microbiome and ImmunityFacility/equipment: Equipment
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CBC Breeding Isolator
Desai, M. (Manager)
Nutrition, Microbiome and ImmunityFacility/equipment: Equipment
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