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NORLUX Neuro-Oncology Laboratory

Organisation profile

Organisation profile

The NORLUX Neuro-Oncology laboratory was set up through a collaborative agreement between LIH and the University of Bergen in Norway based on an extensive collaboration with Prof. Rolf Bjerkvig from the Department of Biomedicine at the University of Bergen. The mission of our lab is to improve the life and prognosis of people affected by a malignant brain tumor.  

We aim to improve the treatment options for malignant brain tumors, with a focus on diffuse gliomas. With a radically translational approach to research, we work with patient samples and innovative patient-derived preclinical model systems that recapitulate the patient tumor. Our research investigates the cellular and molecular basis of gliomas, their capacity to invade the normal brain and escape therapy. Special areas of interests are tumor plasticity, tumor heterogeneity, tumor metabolism, immuno-oncology and pharmacogenomics. 

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  • Acquired genetic and cell-state changes in IDH-mutant glioma progression

    Johnson, K. C., Spitzer, A., Varn, F. S., Nomura, M., Garofano, L., Chowdhury, T., Lipsa, A., Zhang, L., Fernández, E. C., Barak, T., Gulhan Ercan-Sencicek, A., Peksen, A. B., Anderson, K. J., Tesileanu, C. M. S., Amin, S. B., Kocakavuk, E., Zhao, D., D’Angelo, F., Migliozzi, S. & Bussema, L. & 31 others, Gritsch, S., Moon, H. E., Paek, S. H., Bielle, F., Laurenge, A., Di Stefano, A. L., Mathon, B., Picca, A., Sanson, M., Hau, A. C., Hertel, F., Grzyb, K., Zhao, Z., Wang, Q., Jiang, T., Miller, J. J., Wakimoto, H., Cahill, D. P., Moliterno, J., Günel, M., Hermes, B., Sanai, N., Golebiewska, A., Niclou, S. P., Huse, J., Alfred Yung, W. K., Lasorella, A., Suvà, M. L., Iavarone, A., Tirosh, I. & Verhaak, R. G. W., Jul 2026, In: Nature. 655, 8124, p. 1048-1059 12 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    4 Citations (Scopus)

  • CDK12/CDK13 inhibition disrupts transcriptional elongation and replication fork progression in glioblastoma

    Lier, S., Markusson, S. B., Kocijancic, A., Narum, M., Lund, S. O., Böllering, B., Lipsa, A., Søegaard, M. L. C., Rein, I. D., Santha, P., Jain, P., Lång, A., Lång, E., Meyer, N., Dutta, A., Anand, S., Badugu, S. B., Nesse, G. J., Forstrøm, R. J. & Klungland, A. & 10 others, Anand, A., Pollard, S. M., Bøe, S. O., Rinholm, J. E., Frauenknecht, K. B. M., Golebiewska, A., Niclou, S. P., Somyajit, K., Lerdrup, M. & Pandey, D. P., May 2026, In: EMBO Molecular Medicine. 18, 5, p. 1592-1624 33 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    3 Citations (Scopus)

  • Circulating immune profiling reveals impaired monocyte states and trajectories driving immunosuppression in glioblastoma

    Scafidi, A., Kaoma, T., Cerella, C., Campus, E., Grzyb, K., Nosirov, B., Lind-Holm Mogensen, F., Klein, E., Da Costa, R., Skupin, A., Hertel, F., Berchem, G., Mittelbronn, M., Cosma, A., Melin, B., Niclou, S. P., Nazarov, P. V., Golebiewska, A., Poli, A. & Michelucci, A., 16 Jul 2026, In: Journal of Neuroinflammation . 23, 1, 306.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
View all 302 research outputs